Serotype-specific mortality from invasive Streptococcus pneumoniae disease revisited.
Serotype-specific mortality from invasive Streptococcus pneumoniae disease revisited.
复制标题
DOI：
10.1186/1471-2334-4-21
复制
发表时间：
2004-06-30
影响因子：
3.7
通讯作者：
Benfield T
中科院分区：
文献类型：
--
作者：
Martens P;Worm SW;Lundgren B;Konradsen HB;Benfield T
肺炎链球菌（肺炎球菌）的侵袭性感染导致显著的发病率和死亡率。病例系列和实验数据表明，荚膜血清型参与发病机制和疾病结局的决定因素。回顾性分析1990年至2001年诊断的464例成人浸润性疾病。多变量考克斯比例风险分析。在调整疾病严重程度的其他标志物后，我们发现血清3型感染与死亡的相对风险（RR）增加2.54（95%置信区间（CI）：1.22-5.27）相关，而血清1型感染与死亡风险降低相关（RR 0.23（95% CI，0.06-0.97））。此外，年龄较大、相对白细胞减少和相对体温过低是死亡率的独立预测因素。我们的研究表明，荚膜血清型独立影响侵袭性肺炎球菌疾病的结果。目前多糖肺炎球菌疫苗的局限性保证了替代疫苗的开发。我们建议在设计新型疫苗时应考虑肺炎球菌血清型的毒力。
Invasive infection with Streptococcus pneumoniae (pneumococci) causes significant morbidity and mortality. Case series and experimental data have shown that the capsular serotype is involved in the pathogenesis and a determinant of disease outcome. Retrospective review of 464 cases of invasive disease among adults diagnosed between 1990 and 2001. Multivariate Cox proportional hazard analysis. After adjustment for other markers of disease severity, we found that infection with serotype 3 was associated with an increased relative risk (RR) of death of 2.54 (95% confidence interval (CI): 1.22–5.27), whereas infection with serotype 1 was associated with a decreased risk of death (RR 0.23 (95% CI, 0.06–0.97)). Additionally, older age, relative leucopenia and relative hypothermia were independent predictors of mortality. Our study shows that capsular serotypes independently influenced the outcome from invasive pneumococcal disease. The limitations of the current polysaccharide pneumococcal vaccine warrant the development of alternative vaccines. We suggest that the virulence of pneumococcal serotypes should be considered in the design of novel vaccines.
登录
查看更多内容
影响因子：
158.5
作者：
Klugman, KP;Madhi, SA;Pierce, N
通讯作者：
Pierce, N
影响因子：
3.1
作者：
KELLY, T;DILLARD, JP;YOTHER, J
通讯作者：
YOTHER, J
影响因子：
3.1
作者：
BRILES, DE;CRAIN, MJ;YOTHER, J
通讯作者：
YOTHER, J
影响因子：
3.1
作者：
delosToyos, JR;Mendez, FJ;Mitchell, TJ
通讯作者：
Mitchell, TJ
影响因子：
39.2
作者：
AUSTRIAN, R;GOLD, J
通讯作者：
GOLD, J