Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men.
Impact of severity, duration, and etiology of hyperthyroidism on bone turnover markers and bone mineral density in men.
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DOI：
10.1186/1472-6823-11-15
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发表时间：
2011-08-06
影响因子：
2.7
通讯作者：
El Atta MA
中科院分区：
文献类型：
--
作者：
El Hadidy el HM;Ghonaim M;El Gawad SSh;El Atta MA
甲亢伴骨质疏松，骨折发生率较高。本研究旨在研究甲亢患者的骨状态，并阐明甲亢的严重程度、持续时间和病因对骨转换和骨密度（BMD）生化指标的影响。纳入男性甲状腺功能亢进患者52例，其中格雷夫斯病（GD） 31例，中毒性多结节性甲状腺肿（TNG） 21例，年龄23 ~ 65岁，与年龄相匹配的健康甲状腺功能正常男性25例作为对照组。除了全面的临床检查外，患者和对照组还使用双能x线吸收仪扫描左桡骨下半部分测量骨密度。同时，对所有患者和对照组进行骨转换的一些生化标记。骨转换生化指标：GD和TNG患者血清骨特异性碱性磷酸酶、骨钙素、l型胶原羧基末端端肽、尿脱氧吡啶啉交联（DXP）、尿DXP/尿肌酐比、尿钙/尿肌酐比均显著高于对照组（P < 0.01）。而GD与TNG患者在这些参数上差异无统计学意义（P < 0.05）。GD组和TNG组骨密度明显低于对照组，但GD组左桡骨下半部分骨密度z评分（-1.7±0.5 SD）与TNG组（-1.6±0.6 SD）差异无统计学意义（>0.05）。游离T3、游离T4与骨转换生化指标呈显著正相关，TSH与骨转换生化指标呈显著负相关。甲状腺毒性状态的持续时间与评估的骨转换标志物呈正相关，但与所研究的甲状腺功能亢进患者的BMD z评分呈负相关（r = -0.68, P < 0.0001）。甲状腺机能亢进的男性有明显的骨质流失和较高的骨转换生化指标。甲状腺毒状态的严重程度和持续时间与骨转换、骨质流失等生化指标的紊乱有直接关系。
Hyperthyroidism is accompanied by osteoporosis with higher incidence of fracture rates. The present work aimed to study bone status in hyperthyroidism and to elucidate the impact of severity, duration, and etiology of hyperthyroidism on biochemical markers of bone turnover and bone mineral density (BMD). Fifty-two male patients with hyperthyroidism, 31 with Graves' disease (GD) and 21 with toxic multinodular goiter (TNG), with an age ranging from 23 to 65 years were included, together with 25 healthy euthyroid men with matched age as a control group. In addition to full clinical examination, patients and controls were subjected to measurement of BMD using dual-energy X-ray absorptiometery scanning of the lower half of the left radius. Also, some biochemical markers of bone turnover were done for all patients and controls. Biochemical markers of bone turnover: included serum bone specific alkaline phosphatase, osteocalcin, carboxy terminal telopeptide of type l collagen also, urinary deoxypyridinoline cross-links (DXP), urinary DXP/urinary creatinine ratio and urinary calcium/urinary creatinine ratio were significantly higher in patients with GD and TNG compared to controls (P < 0.01). However, there was non-significant difference in these parameters between GD and TNG patients (P > 0.05). BMD was significantly lower in GD and TNG compared to controls, but the Z-score of BMD at the lower half of the left radius in patients with GD (-1.7 ± 0.5 SD) was not significantly different from those with TNG (-1.6 ± 0.6 SD) (>0.05). There was significant positive correlation between free T3 and free T4 with biochemical markers of bone turnover, but negative correlation between TSH and those biochemical markers of bone turnover. The duration of the thyrotoxic state positively correlated with the assessed bone turnover markers, but it is negatively correlated with the Z-score of BMD in the studied hyperthyroid patients (r = -0.68, P < 0.0001). Men with hyperthyroidism have significant bone loss with higher biochemical markers of bone turnover. The severity and the duration of the thyrotoxic state are directly related to the derangement of biochemical markers of bone turnover and bone loss.
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影响因子：
9.3
作者：
Kraenzlin, Marius E.;Kraenzlin, Claude A.;Steinmann, Beat
通讯作者：
Steinmann, Beat
DOI：
10.1016/s0169-6009(08)80115-8
发表时间：
1993-04-01
期刊：
BONE AND MINERAL
影响因子：
--
作者：
CAMPOSPASTOR, MM;MUNOZTORRES, M;GIMENO, EJ
通讯作者：
GIMENO, EJ
影响因子：
5.8
作者：
Heijckmann, AC;Huijberts, MSP;Wolffenbuttel, BHR
通讯作者：
Wolffenbuttel, BHR
影响因子：
5.8
作者：
LEE, MS;KIM, SY;MIN, HK
通讯作者：
MIN, HK
影响因子：
2.2
作者：
Barsal, G;Taneli, F;Erciyas, F
通讯作者：
Erciyas, F