Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing.
Fabrication, characterization, and in vitro evaluation of silver-containing arabinoxylan foams as antimicrobial wound dressing.
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将含白银的阿拉伯素泡沫作为抗菌伤口敷料的制造，表征和体外评估。
DOI：
10.1002/jbm.a.35783
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发表时间：
2016-10
影响因子：
4.9
通讯作者：
Yang, Hu
中科院分区：
文献类型：
--
作者：
Aduba, Donald C., Jr.;An, Seon-Sook;Selders, Gretchen S.;Wang, Juan;Yeudall, W. Andrew;Bowlin, Gary L.;Kitten, Todd;Yang, Hu
关键词：
通过酶促过氧化物酶/过氧化氢交联反应制备阿魏酸阿拉伯木聚糖（AXF）泡沫，然后冷冻干燥，并研究其作为潜在的伤口敷料材料。考察了AXF泡沫的流变性能、形态结构、孔隙率和溶胀性能。AXF泡沫被发现是一种粘弹性材料，被证明是高度多孔和吸水性。AXF泡沫具有低内毒素水平，并与成纤维细胞相容。将银成功地整合到AXF泡沫中并在48小时内缓慢释放。根据改良的Kirby-Bauer纸片扩散敏感性试验，用银浸渍的AXF泡沫显示出抑制细菌生长的功效。总体而言，AXF泡沫具有适当的材料特性，载银AXF泡沫显示出抗菌活性，有必要成为伤口敷料开发的候选材料。
Arabinoxylan ferulate (AXF) foams were fabricated via enzymatic peroxidase/hydrogen peroxide crosslinking reaction followed by freeze-drying and studied as a potential wound dressing material. The AXF foam’s rheological, morphological, porous and swelling properties were examined. AXF foams were found to be a viscoelastic material that proved to be highly porous and water absorbent. AXF foams possessed low endotoxin levels and were cytocompatible with fibroblasts. Silver was successfully integrated into AXF foams and slowly released over 48 hours. AXF foams impregnated with silver demonstrated efficacy inhibiting bacterial growth according to a modified Kirby-Bauer disk diffusion susceptibility test. Overall, AXF foams possess appropriate material properties and the silver-loaded AXF foams showed antimicrobial activity, necessary to be a candidate material in wound dressing development.
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影响因子：
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