Hormesis results in trade-offs with immunity.
Hormesis results in trade-offs with immunity.
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DOI：
10.1111/evo.12453
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发表时间：
2014-08
期刊：
影响因子：
--
通讯作者：
Priest NK
中科院分区：
文献类型：
--
作者：
McClure CD;Zhong W;Hunt VL;Chapman FM;Hill FV;Priest NK
许多人认为，我们可能能够通过毒物兴奋效应，低水平毒素和其他压力的有益影响来延长寿命和改善人类健康。但是，模型系统中的兴奋效应研究尚未确定压力诱导的益处是否是无成本的，近亲繁殖的人工制品，或者具有有害的副作用。在这里，我们提供的证据表明，毒物兴奋效应的结果与免疫力的权衡。我们发现，一个单一的局部剂量的死孢子的昆虫病原真菌，绿僵菌robertsii，增加寿命的果蝇，黑腹果蝇，没有显着降低繁殖力。我们发现病原体挑战的激素效益在缺乏抗真菌免疫关键成分的品系中更大（Dif和Turandot M）。而且，在远交的苍蝇品系中，我们发现局部病原体的挑战提高了存活率和繁殖力，但降低了抵抗活体感染的能力。结果提供的证据表明，毒物兴奋效应表现为压力引起的权衡与免疫，而不是免费的好处或文物近亲繁殖。我们的研究结果阐明了病原体诱导的生命史权衡的潜在机制，并表明免疫功能降低可能是“生命灵药”的一个具有讽刺意味的副作用。
Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost free, artifacts of inbreeding, or come with deleterious side effects. Here, we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines that lack key components of antifungal immunity (Dif and Turandot M). And, in outbred fly lines, we find that topical pathogen challenge enhances both survival and fecundity, but reduces ability to fight off live infections. The results provide evidence that hormesis is manifested by stress-induced trade-offs with immunity, not cost-free benefits or artifacts of inbreeding. Our findings illuminate mechanisms underlying pathogen-induced life-history trade-offs, and indicate that reduced immune function may be an ironic side effect of the “elixirs of life.”
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影响因子：
64.8
作者：
通讯作者：
--
DOI：
10.1006/bbrc.2001.5067
发表时间：
2001-06-22
影响因子：
3.1
作者：
Ekengren, S;Hultmark, D
通讯作者：
Hultmark, D
影响因子：
4.5
作者：
Gao Q;Jin K;Ying SH;Zhang Y;Xiao G;Shang Y;Duan Z;Hu X;Xie XQ;Zhou G;Peng G;Luo Z;Huang W;Wang B;Fang W;Wang S;Zhong Y;Ma LJ;St Leger RJ;Zhao GP;Pei Y;Feng MG;Xia Y;Wang C
通讯作者：
Wang C
DOI：
10.1098/rstb.2010.0276
发表时间：
2011-01-12
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
--
作者：
Kenyon C
通讯作者：
Kenyon C
影响因子：
2.1
作者：
Brun, S;Vidal, S;Lemaitre, B
通讯作者：
Lemaitre, B