The Microbiome in Cystic Fibrosis.

The Microbiome in Cystic Fibrosis.
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囊性纤维化中的微生物组。

DOI:
10.1016/j.ccm.2015.10.003
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发表时间:
2016-03
影响因子:
5.7
通讯作者:
LiPuma JJ
LiPuma JJ
中科院分区:
医学3区
文献类型:
--
作者:
Huang YJ;LiPuma JJ

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过去十年的研究观察结果改变了囊性纤维化(CF)微生物学的传统观点,该观点传统上关注于有限的机会性细菌病原体。现在人们认识到,CF气道通常含有复杂的微生物群落,这些群落的结构和活性的变化对患者的临床状况和肺部疾病的进展有影响。最近对肠道微生物群的研究还表明,CF 胃肠道细菌生态紊乱与肺部结局相关。这些新见解可能会改变未来 CF 的临床管理。
Observations from studies during the last decade have changed the conventional view of cystic fibrosis (CF) microbiology, which has traditionally focused on a limited suite of opportunistic bacterial pathogens. It is now appreciated that CF airways typically harbor complex microbial communities, and that changes in the structure and activity of these communities have a bearing on patient clinical condition and lung disease progression. Recent studies of gut microbiota also suggest that disordered bacterial ecology of the CF gastrointestinal tract is associated with pulmonary outcomes. These new insights may alter future clinical management of CF.
DOI: 10.1016/j.jcf.2012.04.006
发表时间: 2012-09
期刊: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
影响因子: --
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