Cortisol's effects on hippocampal activation in depressed patients are related to alterations in memory formation.
Cortisol's effects on hippocampal activation in depressed patients are related to alterations in memory formation.
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DOI：
10.1016/j.jpsychires.2010.10.005
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发表时间：
2011-01
影响因子：
4.8
通讯作者：
Halverson J
中科院分区：
文献类型：
--
作者：
Abercrombie HC;Jahn AL;Davidson RJ;Kern S;Kirschbaum C;Halverson J
许多研究人员假设大脑对皮质醇的反应在抑郁症中发生了改变。然而，尚未在抑郁症患者中直接检查对外源操纵的皮质醇升高做出的神经激活反应。动物研究表明，糖皮质激素对海马功能具有强大的影响，并且可以根据多种因素增强或抑制海马的神经塑性事件。我们假设抑郁症患者会表现出：1）海马对外源性皮质醇的反应发生改变，2）皮质醇对学习的影响发生改变。在重复测量设计中，19 名未接受药物治疗的抑郁症患者和 41 名健康人完成了两次功能磁共振成像扫描。在功能磁共振成像扫描期间编码情绪和中性词之前一小时，给予 15 毫克口服氢化可的松（即皮质醇）或安慰剂（随机顺序和双盲）。数据分析检查了皮质醇给药对 1）编码期间大脑激活和 2）随后的单词自由回忆的影响。皮质醇会影响抑郁症患者随后的回忆表现，但不会影响健康人。我们发现抑郁女性的海马对皮质醇的反应发生了变化，但抑郁男性则没有（他们的其他区域，包括膝下前额皮质）对皮质醇的反应发生了变化。在抑郁的男性和女性中，皮质醇对海马功能的影响与几天后评估的回忆表现的影响呈正相关。我们的数据提供的证据表明，与健康女性相比，抑郁女性的皮质醇对海马功能的影响发生了变化。我们的数据还表明，在抑郁的男性和女性中，皮质醇对情绪记忆形成和海马功能的影响是相关的。
Many investigators have hypothesized that brain response to cortisol is altered in depression. However, neural activation in response to exogenously manipulated cortisol elevations has not yet been directly examined in depressed humans. Animal research shows that glucocorticoids have robust effects on hippocampal function, and can either enhance or suppress neuroplastic events in the hippocampus depending on a number of factors. We hypothesized that depressed individuals would show 1) altered hippocampal response to exogenous administration of cortisol, and 2) altered effects of cortisol on learning. In a repeated-measures design, 19 unmedicated depressed and 41 healthy individuals completed two fMRI scans. Fifteen mg oral hydrocortisone (i.e., cortisol) or placebo (order randomized and double-blind) was administered one hour prior to encoding of emotional and neutral words during fMRI scans. Data analysis examined the effects of cortisol administration on 1) brain activation during encoding, and 2) subsequent free recall for words. Cortisol affected subsequent recall performance in depressed but not healthy individuals. We found alterations in hippocampal response to cortisol in depressed women, but not in depressed men (who showed altered response to cortisol in other regions, including subgenual prefrontal cortex). In both depressed men and women, cortisol’s effects on hippocampal function were positively correlated with its effects on recall performance assessed days later. Our data provide evidence that in depressed compared to healthy women, cortisol’s effects on hippocampal function are altered. Our data also show that in both depressed men and women, cortisol’s effects on emotional memory formation and hippocampal function are related.
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影响因子：
3.1
作者：
Joëls M;Krugers HJ
通讯作者：
Krugers HJ
影响因子：
17.7
作者：
DeBattista, C;Posener, JA;Schatzberg, AF
通讯作者：
Schatzberg, AF
影响因子：
10.5
作者：
Hickie, I;Naismith, S;Parker, G
通讯作者：
Parker, G
影响因子：
24.8
作者：
Leuner B;Gould E
通讯作者：
Gould E
DOI：
10.1073/pnas.95.24.14506
发表时间：
1998-11-24
影响因子：
11.1
作者：
Alkire, MT;Haier, RJ;Cahill, L
通讯作者：
Cahill, L