The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer.
The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer.
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DOI：
10.1080/09553002.2018.1511929
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发表时间：
2018-11
影响因子：
2.6
通讯作者：
Boreham DR
中科院分区：
文献类型：
--
作者：
Puukila S;Thome C;Brooks AL;Woloschak G;Boreham DR
剂量和剂量率都适用于估计内部沉积放射性物质的风险。我们研究了剂量率在单次吸入锶-90 （90Sr）、铈-144 （144Ce）、钇-91 （91Y）或钇-90 （90Y）后诱发比格犬肺癌的作用。由于放射性核素的保留取决于生物清除和物理半衰期，因此需要一个具有代表性的量来描述这种复杂的剂量变化率。数据来自吸入毒理学研究所的比格犬实验。作者选择了每种放射性核素有效半衰期的剂量率（DRef）。暴露于DRef（1-100戈瑞/天）的狗在暴露于急性肺部疾病后一年内死亡。暴露在较低DRef （0.1-10 Gy/d）下的狗死于肺癌。随着DRef进一步降低（90Sr <0.1 Gy/day, 144Ce <0.5 Gy/day, 91Y <0.9 Gy/day, 90Y <8 Gy/day），存活率和肺癌发病率与对照组无显著差异。吸入β - γ放射核素（根据其有效半衰期以不同的速率衰变，导致剂量率和累积剂量降低的速率不同）所造成的辐射照射在致癌方面不如肺部急性低线性能量转移照射有效。
Dose and dose rate are both appropriate for estimating risk from internally deposited radioactive materials. We investigated the role of dose rate on lung cancer induction in Beagle dogs following a single inhalation of strontium-90 (90Sr), cerium-144 (144Ce), yttrium-91 (91Y), or yttrium-90 (90Y). As retention of the radionuclide is dependent on biological clearance and physical half-life a representative quantity to describe this complex changing dose rate is needed. Data were obtained from Beagle dog experiments from the Inhalation Toxicology Research Institute. The authors selected the dose rate at the effective half-life of each radionuclide (DRef). Dogs exposed to DRef (1–100 Gy/day) died within the first year after exposure from acute lung disease. Dogs exposed at lower DRef (0.1–10 Gy/day) died of lung cancer. As DRef decreased further (<0.1 Gy/day 90Sr, <0.5 Gy/day 144Ce, <0.9 Gy/day 91Y, <8 Gy/day 90Y), survival and lung cancer frequency were not significantly different from control dogs. Radiation exposures resulting from inhalation of beta-gamma emitting radionuclides that decay at different rates based on their effective half-life, leading to different rates of decrease in dose rate and cumulative dose, is less effective in causing cancer than acute low linear energy transfer exposures of the lung.
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影响因子：
2.6
作者：
Feinendegen, Ludwig E.;Pollycove, Myron;Neumann, Ronald D.
通讯作者：
Neumann, Ronald D.
影响因子：
120.7
作者：
COTE, RA;ROBBOY, S
通讯作者：
ROBBOY, S
影响因子：
10.3
作者：
HAHN, FF;BENJAMIN, SA;REDMAN, HC
通讯作者：
REDMAN, HC
影响因子：
3.4
作者：
Benjamin, SA;Lee, AC;Mallinckrodt, CH
通讯作者：
Mallinckrodt, CH
影响因子：
3.4
作者：
BARNES, JE;KANAPILLY, GM;MCCLELLAN, RO
通讯作者：
MCCLELLAN, RO