The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage.
The Role of the Blood Neutrophil-to-Lymphocyte Ratio in Aneurysmal Subarachnoid Hemorrhage.
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DOI：
10.3389/fneur.2021.671098
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发表时间：
2021
影响因子：
3.4
通讯作者：
Chen G
中科院分区：
文献类型：
--
作者：
Cai L;Zeng H;Tan X;Wu X;Qian C;Chen G
动脉瘤性蛛网膜下腔出血（aSAH）是一种重要的卒中类型，其死亡率和致残率最高。最近的证据表明，神经炎症在aSAH后的早期脑损伤和迟发性神经退化中起着关键作用，导致不利的结果。嗜中性粒细胞与淋巴细胞比率（NLR）是一种外周生物标志物，可传达先天性和适应性免疫方面的炎症负荷信息。本文综述了NLR与aSAH相关的研究，以评估NLR是否可以预测结局并作为临床管理的有效生物标志物。我们发现NLR增加在预测aSAH患者的临床结局方面很有价值，并且与迟发性脑缺血（DCI）或再出血等并发症的风险相关。结合其他指标，NLR提供了更高的预测预后的准确性，将患者分为不同的风险类别。强调潜在的病理生理学，以确定新的潜在的神经保护靶点，并开发新的治疗策略。
Aneurysmal subarachnoid hemorrhage (aSAH) is an important type of stroke with the highest rates of mortality and disability. Recent evidence indicates that neuroinflammation plays a critical role in both early brain injury and delayed neural deterioration after aSAH, contributing to unfavorable outcomes. The neutrophil-to-lymphocyte ratio (NLR) is a peripheral biomarker that conveys information about the inflammatory burden in terms of both innate and adaptive immunity. This review summarizes relevant studies that associate the NLR with aSAH to evaluate whether the NLR can predict outcomes and serve as an effective biomarker for clinical management. We found that increased NLR is valuable in predicting the clinical outcome of aSAH patients and is related to the risk of complications such as delayed cerebral ischemia (DCI) or rebleeding. Combined with other indicators, the NLR provides improved accuracy for predicting prognosis to stratify patients into different risk categories. The underlying pathophysiology is highlighted to identify new potential targets for neuroprotection and to develop novel therapeutic strategies.
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影响因子：
4.6
作者：
Chalouhi N;Ali MS;Starke RM;Jabbour PM;Tjoumakaris SI;Gonzalez LF;Rosenwasser RH;Koch WJ;Dumont AS
通讯作者：
Dumont AS
影响因子：
4
作者：
Asano S;Chantler PD;Barr TL
通讯作者：
Barr TL
DOI：
10.1136/bmj.k4079
发表时间：
2018-09-26
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.6
作者：
Chen, Jinman;Wang, Linmei;Wang, Yongjun
通讯作者：
Wang, Yongjun
CX3CL1/CX3CR1轴通过促进蛛网膜下腔出血后外泌体microRNA-124从神经元向小胶质细胞的递送来减轻早期脑损伤
影响因子：
9.3
作者：
Chen, Xiao;Jiang, Ming;Chen, Gang
通讯作者：
Chen, Gang