LbL Nano-Assemblies: A Versatile Tool for Biomedical and Healthcare Applications.

LbL Nano-Assemblies: A Versatile Tool for Biomedical and Healthcare Applications.
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DOI:
10.3390/nano12060949
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发表时间:
2022-03-14
期刊:
Nanomaterials (Basel, Switzerland)
影响因子:
--
通讯作者:
Rahdar A
Rahdar A
中科院分区:
其他
文献类型:
--
作者:
Díez-Pascual AM;Rahdar A

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聚电解质(PE)在过去几年中一直是许多研究的目标。PE膜是通过简单而多功能的逐层(LbL)方法制备的,该方法使用涉及聚阴离子和聚阳离子的聚合物对的交替组装。交替PE多层的吸附由不同的力驱动(即,静电相互作用、氢键、电荷转移相互作用、疏水力等),其能够精确控制膜的物理性质(即,纳米级的厚度和形态)。这些PE纳米组装体具有广泛的生物医学和医疗保健应用,包括药物递送、蛋白质递送、组织工程、伤口愈合等。这篇评论提供了一个简明扼要的概述最突出的研究设计和制造的PE纳米薄膜。它们的纳米结构,分子与生物分子的相互作用,以及在生物医学领域的应用进行了简要讨论。最后,强调了用于医疗保健和医疗应用的LbL纳米组装体开发的进一步研究方向的前景。
Polyelectrolytes (PEs) have been the aim of many research studies over the past years. PE films are prepared by the simple and versatile layer-by-layer (LbL) approach using alternating assemblies of polymer pairs involving a polyanion and a polycation. The adsorption of the alternating PE multiple layers is driven by different forces (i.e., electrostatic interactions, H-bonding, charge transfer interactions, hydrophobic forces, etc.), which enable an accurate control over the physical properties of the film (i.e., thickness at the nanoscale and morphology). These PE nano-assemblies have a wide range of biomedical and healthcare applications, including drug delivery, protein delivery, tissue engineering, wound healing, and so forth. This review provides a concise overview of the most outstanding research on the design and fabrication of PE nanofilms. Their nanostructures, molecular interactions with biomolecules, and applications in the biomedical field are briefly discussed. Finally, the perspectives of further research directions in the development of LbL nano-assemblies for healthcare and medical applications are highlighted.
通过逐层组装构建的基于介孔二氧化硅的多功能治疗诊断纳米平台,可实现出色的光动力/化疗治疗
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