Dynamic Musculoskeletal Functional Morphology: Integrating diceCT and XROMM.
Dynamic Musculoskeletal Functional Morphology: Integrating diceCT and XROMM.
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动态肌肉骨骼功能形态：整合diCect和Xromm。
DOI：
10.1002/ar.23714
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Ross CF
中科院分区：
文献类型：
--
作者：
Orsbon CP;Gidmark NJ;Ross CF
骨骼肌力和速度之间的权衡是脊椎动物肌肉骨骼设计(形式：功能关系)的基本约束。了解不同谱系如何以及为什么解决这一生物力学问题是脊椎动物肌肉骨骼功能形态学的一个重要目标。我们回答有关这种权衡的不同解决方案的问题的能力因肌肉骨骼形态和运动量化技术的最新进展而显著提高。在此，我们有三个目标：(1)综述影响肌肉功能的形态和生理参数以及这些参数是如何相互作用的；(2)讨论整合形态和生理证据以了解肌肉功能的必要性以及实现这一目的的新的高分辨率成像技术；以及(3)提出一种集成高时空分辨率运动捕捉(XROMM，包括其必然的荧光显微测量)、高分辨率软组织成像(DICECT)和肌电图来研究活体肌肉骨骼动力学的方法。该方法是通过对体内灵长类动物咀嚼和吞咽过程中舌液生物力学的案例研究来演示的。灵敏度分析表明，重建舌骨肌肉附着位置的微小偏差对活体肌肉运动学的平均误差为13.2%。观察到的舌骨和肌肉运动学表明，舌骨抬高是由多块肌肉产生的，而肌束旋转和肌腱张力将舌骨运动和整个肌肉长度的肌束张力分离。最后，我们强调了这些技术目前的局限性，其中一些可能很快就会通过改进方法来克服，其中一些是固有的。
The tradeoff between force and velocity in skeletal muscle is a fundamental constraint on vertebrate musculoskeletal design (form:function relationships). Understanding how and why different lineages address this biomechanical problem is an important goal of vertebrate musculoskeletal functional morphology. Our ability to answer questions about the different solutions to this tradeoff has been significantly improved by recent advances in techniques for quantifying musculoskeletal morphology and movement. Herein, we have three objectives: (1) review the morphological and physiological parameters that affect muscle function and how these parameters interact; (2) discuss the necessity of integrating morphological and physiological lines of evidence to understand muscle function and the new, high resolution imaging technologies that do so; and (3) present a method that integrates high spatiotemporal resolution motion capture (XROMM, including its corollary fluoromicrometry), high resolution soft tissue imaging (diceCT), and electromyography to study musculoskeletal dynamics in vivo. The method is demonstrated using a case study of in vivo primate hyolingual biomechanics during chewing and swallowing. A sensitivity analysis demonstrates that small deviations in reconstructed hyoid muscle attachment site location introduce an average error of 13.2% to in vivo muscle kinematics. The observed hyoid and muscle kinematics suggest that hyoid elevation is produced by multiple muscles and that fascicle rotation and tendon strain decouple fascicle strain from hyoid movement and whole muscle length. Lastly, we highlight current limitations of these techniques, some of which will likely soon be overcome through methodological improvements, and some of which are inherent.
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