N-Acetylaspartate and Choline Metabolites in Cortical and Subcortical Regions in Clinical High Risk Relative to Healthy Control Subjects: An Exploratory 7T MRSI Study.
N-Acetylaspartate and Choline Metabolites in Cortical and Subcortical Regions in Clinical High Risk Relative to Healthy Control Subjects: An Exploratory 7T MRSI Study.
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DOI：
10.3390/ijms24097682
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发表时间：
2023-04-22
影响因子：
5.6
通讯作者：
Ferrarelli, Fabio
中科院分区：
文献类型：
--
作者：
Mayeli, Ahmad;Janssen, Sabine A.;Huston, Chloe A.;Rupp, Julia S.;Sharma, Kamakashi;Moon, Chan-Hong;Keihani, Ahmadreza;Hetherington, Hoby P.;Ferrarelli, Fabio
N-乙酰天冬氨酸（NAA）和胆碱（Cho）是两种脑代谢物，涉及几个关键的神经功能。在早期病程和慢性精神分裂症（SCZ）患者中，这些代谢产物的减少均有报道。然而，目前尚不清楚NAA和Cho的改变是否发生在疾病发作之前。临床高风险（clinical high risk，SCZ）个体是精神病和SCZ独特富集的人群。在这项探索性研究中，我们利用7特斯拉磁共振波谱成像（MRSI）检查总NAA（tNAA; NAA + N-乙酰基谷氨酸[NAAG]）和主要含胆碱化合物，包括甘油磷酸胆碱和磷酸胆碱[tCho]，在26名健康受试者和32名健康对照（HC）受试者之间的皮质下和皮质区域的肌酸（Cre）水平的差异。虽然在任何感兴趣的区域（ROI）中没有发现组间tCho/Cre差异，但我们发现，与HC相比，RNS在右侧背外侧前额叶皮层（DLPFC）中显著降低了tNAA/Cre，并且RNS的右侧DLPFC tNAA/Cre降低与其阳性症状评分呈负相关。在其他感兴趣区中，没有发现tNAA/Cre在HCM和HC之间的差异。总之，降低tNAA/Cre在hcv与HC可能代表一个假定的分子生物标志物的精神病和SCZ的风险与症状的严重程度。
N-acetylaspartate (NAA) and choline (Cho) are two brain metabolites implicated in several key neuronal functions. Abnormalities in these metabolites have been reported in both early course and chronic patients with schizophrenia (SCZ). It is, however, unclear whether NAA and Cho’s alterations occur even before the onset of the disorder. Clinical high risk (CHR) individuals are a population uniquely enriched for psychosis and SCZ. In this exploratory study, we utilized 7-Tesla magnetic resonance spectroscopic imaging (MRSI) to examine differences in total NAA (tNAA; NAA + N-acetylaspartylglutamate [NAAG]) and major choline-containing compounds, including glycerophosphorylcholine and phosphorylcholine [tCho], over the creatine (Cre) levels between 26 CHR and 32 healthy control (HC) subjects in the subcortical and cortical regions. While no tCho/Cre differences were found between groups in any of the regions of interest (ROIs), we found that CHR had significantly reduced tNAA/Cre in the right dorsal lateral prefrontal cortex (DLPFC) compared to HC, and that the right DLPFC tNAA/Cre reduction in CHR was negatively associated with their positive symptoms scores. No tNAA/Cre differences were found between CHR and HC in other ROIs. In conclusion, reduced tNAA/Cre in CHR vs. HC may represent a putative molecular biomarker for risk of psychosis and SCZ that is associated with symptom severity.
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影响因子：
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