Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells.
Epigenetic distortion to VDR transcriptional regulation in prostate cancer cells.
复制标题
对前列腺癌细胞中VDR转录调控的表观遗传扭曲。
DOI：
10.1016/j.jsbmb.2012.10.002
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发表时间：
2013-07
影响因子：
4.1
通讯作者：
Campbell, Moray J.
中科院分区：
文献类型：
--
作者：
Singh, Prashant K.;Doig, Craig L.;Dhiman, Vineet K.;Turner, Bryan M.;Smiraglia, Dominic J.;Campbell, Moray J.
The current study aimed to examine the gene specific mechanisms by which the actions of the vitamin D receptor (VDR) are distorted in prostate cancer. Transcriptional responses toward the VDR ligand, 1α,25(OH)2D3, were examined in non-malignant prostate epithelial cells (RWPE-1) and compared to the 1α,25(OH)2D3-recalcitrant prostate cancer cells (PC-3). Time resolved transcriptional studies for two VDR target genes revealed selective attenuation and repression of VDR transcriptional responses in PC-3 cells. For example, responses in PC-3 cells revealed suppressed responsiveness of IGFBP3 and G0S2. Furthermore, Chromatin Immunoprecipitation (ChIP) assays revealed that suppressed transcriptional responses in PC-3 cells of IGFBP3 and G0S2 were associated with selective VDR-induced NCOR1 enrichment at VDR-binding regions on target-gene promoter regions. We propose that VDR inappropriately recruits co-repressors in prostate cancer cells. Subsequent direct and indirect mechanisms may induce local DNA methylation and stable transcriptional silencing. Thus a transient epigenetic process mediated by co-repressor binding, namely, the control of H3K9 acetylation, is distorted to favor a more stable epigenetic event, namely DNA methylation.
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影响因子：
29
作者：
Barish GD;Yu RT;Karunasiri MS;Becerra D;Kim J;Tseng TW;Tai LJ;Leblanc M;Diehl C;Cerchietti L;Miller YI;Witztum JL;Melnick AM;Dent AL;Tangirala RK;Evans RM
通讯作者：
Evans RM
影响因子：
64.8
作者：
CHEN, JD;EVANS, RM
通讯作者：
EVANS, RM
影响因子：
10.5
作者：
Esteve, Pierre-Olivier;Chin, Hang Gyeong;Pradhan, Sriharsa
通讯作者：
Pradhan, Sriharsa
影响因子：
5.1
作者：
GARLAND, FC;GARLAND, CF;YOUNG, JF
通讯作者：
YOUNG, JF
影响因子：
64.5
作者：
Bookout, Angie L.;Jeong, Yangsik;Mangelsdorf, David J.
通讯作者：
Mangelsdorf, David J.