Spinal interleukin-10 therapy to treat peripheral neuropathic pain.
Spinal interleukin-10 therapy to treat peripheral neuropathic pain.
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DOI：
10.1111/j.1525-1403.2012.00462.x
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Mahoney MJ
中科院分区：
文献类型：
--
作者：
Milligan ED;Penzkover KR;Soderquist RG;Mahoney MJ
Current research indicates that chronic peripheral neuropathic pain includes a role for glia and the actions of proinflammatory factors. This review briefly discusses the glial and cytokine responses that occur following peripheral nerve damage in support of utilizing anti-inflammatory cytokine interleukin-10 therapy to suppress chronic peripheral neuropathic pain. IL-10 is one of the most powerful endogenous counter-regulators of pro-inflammatory cytokine function that acts in the nervous system. Subarachnoid (intrathecal) spinal injection of the gene encoding IL-10 delivered by non-viral vectors has several advantages over virally-mediated gene transfer methods and leads to profound pain relief in several animal models. Lastly, data are reviewed that non-viral DNA encapsulated by a biologically safe co-polymer, poly(lactic-co-glycolic) acid (PLGA), thought to protect DNA, leads to significantly improved therapeutic gene transfer in animal models, which additionally and significantly extends pain relief. The impact of these early studies exploring anti-inflammatory genes emphasizes the exceptional therapeutic potential of new biocompatible intrathecal non-viral gene delivery approaches such as PLGA microparticles. Ultimately, ongoing expression of therapeutic genes are a viable option to treat chronic neuropathic pain in the clinic.
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DOI：
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