Visualized peritoneal fluid variation in adolescents and young adults with endometriosis: is there more to it?
Visualized peritoneal fluid variation in adolescents and young adults with endometriosis: is there more to it?
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DOI：
10.3389/frph.2023.1297907
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发表时间：
2023
影响因子：
--
通讯作者：
Sasamoto, Naoko
中科院分区：
文献类型：
--
作者：
Yousif, Abdelrahman;DePari, Mary;Vitonis, Allison F.;Harris, Holly R.;Shafrir, Amy L.;Terry, Kathryn L.;Missmer, Stacey A.;Sasamoto, Naoko
腹膜液是发现子宫内膜异位症相关生物标志物的媒介，可以推断局部腹膜环境和病理生理途径。因此，我们评估了与子宫内膜异位症相关的腹腔镜手术时腹膜液颜色和体积与患者特征、子宫内膜异位症类型和病变位置之间的关系。我们对545名接受子宫内膜异位症手术的患者进行了横断面分析，这些患者参加了“妇女健康研究：从青春期到成年期队列研究”。按照世界子宫内膜异位症研究基金会子宫内膜异位症表型和生物银行协调项目（EPHect）工具收集患者特征、手术可视化子宫内膜异位症表型和腹膜液大体特征。卡方检验或费雪精确检验用于检验类别间的差异。大多数患者为白人（89%）的青少年或青壮年（86%年龄<25岁），手术时仅观察到浅表腹膜病变和rASRM分期为I/II（均为95%）。我们观察到手术时不同月经周期阶段腹膜液颜色的变化（p = 0.006）。在手术时循环的患者中，与分泌期（27%）相比，红色腹膜液的子宫内膜异位症患者最有可能处于增殖期（49%），而黄色或橙色腹膜液的患者最有可能处于分泌期（分别为57%和86%）。服用联合口服避孕药的患者颜色明显变黄，而仅服用黄体酮制剂的患者颜色变黄更为常见（p = 0.002）。腹膜液量在周期阶段没有差异，但在手术时暴露于激素的患者更有可能低（≤6 ml） （p = 0.01）。与无周期性骨盆疼痛的患者相比，有红色腹膜液的可能性较小（p = 0.001），但体积更大（p = 0.02）。我们的研究结果强调了在设计使用腹膜液样本的研究时考虑月经周期阶段和激素暴露的重要性，并从生物标志物结果中进行推断，旨在提高我们对子宫内膜异位症和相关症状病理生理学的理解。
Peritoneal fluid is a medium for endometriosis-associated biomarker discovery from which the local peritoneal environment and pathophysiologic pathways are often inferred. Therefore, we evaluated the associations between peritoneal fluid color and volume at time of endometriosis-related laparoscopic surgery with patient characteristics, endometriosis type and lesion location in adolescents and young adults with endometriosis. We conducted a cross-sectional analysis among 545 patients undergoing surgery for endometriosis who enrolled in the Women's Health Study: from Adolescence to Adulthood cohort study. Patient characteristics, surgically visualized endometriosis phenotypes, and gross characteristics of peritoneal fluid were collected in compliance with World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project (EPHect) tools. Chi-square or Fisher's exact tests were applied to test for differences across categories. Most of the patients were adolescents or young adults (86% age <25 years) of white race (89%), with only superficial peritoneal lesions and rASRM stage = I/II observed at surgery (both 95%). We observed variation in peritoneal fluid color across different menstrual cycle phases at time of surgery (p = 0.006). Among those who were cycling at time of surgery, endometriosis patients with red peritoneal fluid were most likely to be in the proliferative phase (49%) compared to the secretory phase (27%), while those with yellow or orange peritoneal fluid were most likely to be in the secretory phase (57% and 86% respectively). Yellow color was significantly less common in those taking combined oral contraceptives but much more common with progesterone only formulation exposure (p = 0.002). Peritoneal fluid volume did not differ by cycle phase but was more likely to be low (≤6 ml) for those exposed to hormones at time of surgery (p = 0.01). Those with acyclic pelvic pain were less likely to have red peritoneal fluid (p = 0.001) but had greater volume (p = 0.02) compared to those without. Our findings highlight the importance of accounting for menstrual cycle phase and hormonal exposures when designing research using peritoneal fluid samples and inferring from biomarker results intended to advance our understanding of endometriosis and associated symptom pathophysiology.
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影响因子：
6.7
作者：
Becker, Christian M.;Laufer, Marc R.;Stratton, Pamela;Hummelshoj, Lone;Missmer, Stacey A.;Zondervan, Krina T.;Adamson, G. David
通讯作者：
Adamson, G. David
影响因子：
1.7
作者：
Polak, Grzegorz;Barczynski, Barttomiej;Kotarski, Jan
通讯作者：
Kotarski, Jan
影响因子：
13.3
作者：
Koninckx, PR;Kennedy, SH;Barlow, DH
通讯作者：
Barlow, DH
影响因子：
8
作者：
Barlow, Sarah E.
通讯作者：
Barlow, Sarah E.
影响因子：
2.1
作者：
DONNEZ, J;LANGEROCK, S;THOMAS, K
通讯作者：
THOMAS, K