Chromatin regulation and genome maintenance by mammalian SIRT6.
Chromatin regulation and genome maintenance by mammalian SIRT6.
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DOI：
10.1016/j.tibs.2010.07.009
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发表时间：
2011-01
影响因子：
13.8
通讯作者：
Chua, Katrin F.
中科院分区：
文献类型：
--
作者：
Tennen, Ruth I.;Chua, Katrin F.
酿酒酵母Sir2是一种依赖NAD+的组蛋白去乙酰化酶，它将染色质沉默与基因组稳定性、细胞代谢和寿命调节联系起来。在小鼠中，Sir2家族成员SIRT6的缺乏导致基因组不稳定、代谢缺陷和与衰老相关的退行性病理。直到最近，SIRT6是一种孤儿酶，其催化活性和底物尚不清楚。然而，新的机制见解来自于SIRT6是一种高度底物特异性组蛋白去乙酰化酶的发现，它在一些生理环境中促进适当的染色质功能，包括端粒和基因组稳定、基因表达和DNA修复。通过维持哺乳动物基因组的完整性和表达，SIRT6因此发挥了与Sir2功能相似的几种作用。在这里，我们回顾了SIRT6作用机制的最新进展及其对人类生物学和疾病的影响。
Saccharomyces cerevisiae Sir2 is an NAD+-dependent histone deacetylase that links chromatin silencing to genomic stability, cellular metabolism, and lifespan regulation. In mice, deficiency for the Sir2 family member SIRT6 leads to genomic instability, metabolic defects, and degenerative pathologies associated with aging. Until recently, SIRT6 was an orphan enzyme whose catalytic activity and substrates were unclear. However, new mechanistic insights have come from the discovery that SIRT6 is a highly substrate-specific histone deacetylase that promotes proper chromatin function in several physiologic contexts, including telomere and genome stabilization, gene expression, and DNA repair. By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function. Here, we review recent advances in understanding the mechanisms of SIRT6 action and their implications for human biology and disease.
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DOI：
10.1006/bbrc.2000.3000
发表时间：
2000-07-05
影响因子：
3.1
作者：
Frye, RA
通讯作者：
Frye, RA
DOI：
10.1146/annurev.pathol.4.110807.092250
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Haigis MC;Sinclair DA
通讯作者：
Sinclair DA
影响因子：
56.9
作者：
Han, Junhong;Zhou, Hui;Zhang, Zhiguo
通讯作者：
Zhang, Zhiguo
影响因子：
64.8
作者：
HARLEY, CB;FUTCHER, AB;GREIDER, CW
通讯作者：
GREIDER, CW
影响因子：
10.5
作者：
Kaeberlein, M;McVey, M;Guarente, L
通讯作者：
Guarente, L