Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.

Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.
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万古霉素、替考拉宁和瑞斯托菌素苷元甲酯的甲醚衍生物的合成和评价。

DOI:
10.1016/s0960-894x(03)00513-4
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发表时间:
2003
影响因子:
2.7
通讯作者:
Boger,DaleL
Boger,DaleL
中科院分区:
医学4区
文献类型:
--
作者:
McComas,CaseyC;Crowley,BrendanM;Hwang,Inkyu;Boger,DaleL

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A series of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters was synthesized and their antimicrobial activity was established. These derivatives exhibit increased activity against VanB resistant strains of bacteria equipotent with that observed with sensitive bacteria.
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