MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons.
MRI monitoring of macaque monkeys in neuroscience: Case studies, resource and normative data comparisons.
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神经科学中猕猴的核磁共振监测：案例研究，资源和规范数据比较。
DOI：
10.1016/j.neuroimage.2021.117778
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发表时间：
2021-04-15
期刊：
影响因子：
5.7
通讯作者：
Murphy K
中科院分区：
文献类型：
--
作者：
Balezeau F;Nacef J;Kikuchi Y;Schneider F;Rocchi F;Muers RS;Fernandez-Palacios O'Connor R;Blau C;Wilson B;Saunders RC;Howard M 3rd;Thiele A;Griffiths TD;Petkov CI;Murphy K
来自磁共振成像（MRI）的信息对于人类神经系统患者的诊断和治疗管理是有用的。MRI监测也可能被证明对参与神经科学研究的非人类动物有用，前提是MRI可用且可行，并且没有排除扫描的MRI禁忌症。然而，磁共振成像监测没有建立在猕猴和资源是迫切需要的，可以与科学界的贡献增长。在这里，我们展示了基于MRI的监测在几个不同的情况下与猕猴的效用和潜在的好处。我们还在PRIMatE数据交换（PRIME-DE）中建立了PRIMatE MRI监测（PRIME-MRM）资源，并将病例与PRIME-DE中典型猕猴的MRI数据中的规范信息进行定量比较。在这些病例中，猴子没有出现或出现轻度/中度临床体征，其他情况良好，MRI扫描并未显示福利影响显着增加。因此，它们被确定为临床研究、基于MRI的监测和治疗的合适候选者。对于每种情况下，我们显示MRI定量的内部控制有关的治疗步骤和比较与规范性数据在典型的猴子从PRIME-DE。我们发现，MRI有助于精确和早期诊断脑事件，并可用于可视化，治疗和量化治疗反应。科学界现在可以通过其他病例和更大的样本来增加PRIME-MRM资源，以进一步评估和增加灵长类动物MRI监测益处的证据基础，补充动物的临床监测和治疗方案。
Information from Magnetic Resonance Imaging (MRI) is useful for diagnosis and treatment management of human neurological patients. MRI monitoring might also prove useful for non-human animals involved in neuroscience research provided that MRI is available and feasible and that there are no MRI contra-indications precluding scanning. However, MRI monitoring is not established in macaques and a resource is urgently needed that could grow with scientific community contributions. Here we show the utility and potential benefits of MRI-based monitoring in a few diverse cases with macaque monkeys. We also establish a PRIMatE MRI Monitoring (PRIME-MRM) resource within the PRIMatE Data Exchange (PRIME-DE) and quantitatively compare the cases to normative information drawn from MRI data from typical macaques in PRIME-DE. In the cases, the monkeys presented with no or mild/moderate clinical signs, were well otherwise and MRI scanning did not present a significant increase in welfare impact. Therefore, they were identified as suitable candidates for clinical investigation, MRI-based monitoring and treatment. For each case, we show MRI quantification of internal controls in relation to treatment steps and comparisons with normative data in typical monkeys drawn from PRIME-DE. We found that MRI assists in precise and early diagnosis of cerebral events and can be useful for visualising, treating and quantifying treatment response. The scientific community could now grow the PRIME-MRM resource with other cases and larger samples to further assess and increase the evidence base on the benefits of MRI monitoring of primates, complementing the animals’ clinical monitoring and treatment regime.
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影响因子：
5.5
作者：
Menjot de Champfleur, N;Menjot de Champfleur, S;Bonafe, A
通讯作者：
Bonafe, A
DOI：
10.1093/cercor/bhx092
发表时间：
2017-06-01
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Rinne T;Muers RS;Salo E;Slater H;Petkov CI
通讯作者：
Petkov CI
影响因子：
3.7
作者：
Foroozan, Rod
通讯作者：
Foroozan, Rod
影响因子：
0.8
作者：
Li, Chun-Xia;Kempf, Doty J.;Zhang, Xiaodong
通讯作者：
Zhang, Xiaodong
影响因子：
16.2
作者：
PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium. Electronic address: michael.milham@childmind.org;PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium
通讯作者：
PRIMatE Data Exchange (PRIME-DE) Global Collaboration Workshop and Consortium