Effect of hypertriglyceridemia in dyslipidemia-induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study.
Effect of hypertriglyceridemia in dyslipidemia-induced impaired glucose tolerance and sex differences in dietary features associated with hypertriglyceridemia among the Japanese population: The Gifu Diabetes Study.
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DOI：
10.1111/jdi.13398
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发表时间：
2021-05
影响因子：
3.2
通讯作者：
Gifu Diabetes Study Group
中科院分区：
文献类型：
--
作者：
Nonoyama Y;Yamamoto M;Oba S;Horikawa Y;Nagata C;Yabe D;Takeda J;Gifu Diabetes Study Group
日本个体高甘油三酯血症诱导糖耐量受损的机制尚不清楚。我们的目的是评估高甘油三酯血症对葡萄糖代谢的影响，并与低密度脂蛋白水平升高或高密度脂蛋白水平降低进行比较，并阐明日本个体中与高甘油三酯血症相关的饮食摄入的性别差异。我们在岐阜糖尿病研究中随机选择了898名（384名男性和514名女性）年龄在40-78岁之间的参与者；排除因血脂异常或糖尿病而服用药物的患者。横断面测量血清葡萄糖代谢参数水平和食物频率。5年后再次测定糖化血红蛋白。无论男女，高甘油三酯组的葡萄糖代谢参数和糖耐量受损个体的百分比都明显更高。在低高密度脂蛋白组中也观察到类似的趋势，但仅在男性中。同时，只有高-低密度脂蛋白组胰岛素抵抗的稳态模型评估更高。在非肥胖男性中，高甘油三酯组从酒精中摄入的能量占每日总能量摄入的百分比明显更高。在肥胖女性中，高甘油三酯组的总能量摄入明显更大。在5年的随访中，男性糖化血红蛋白水平升高并高甘油三酯血症的风险增加。与低密度脂蛋白升高或高密度脂蛋白降低相比，高甘油三酯血症是糖耐量受损的更强危险因素。对于饮食习惯，非肥胖男性每日酒精能量摄入增加和肥胖女性总能量摄入增加与高甘油三酯血症相关。高甘油三酯血症通过增加胰岛素抵抗和分泌而对葡萄糖代谢产生负面影响。此外，这种效果比高LDL或低HDL胆固醇血症更强，在日本患有血脂异常引起的糖耐量受损。对于饮食习惯，非肥胖男性每日酒精能量摄入增加和肥胖女性总能量摄入增加与高甘油三酯血症相关。
The mechanisms underlying hypertriglyceridemia‐induced impaired glucose tolerance in Japanese individuals remain unclear. We aimed to evaluate the effect of hypertriglyceridemia on glucose metabolism in comparison with that of increased low‐density lipoprotein or decreased high‐density lipoprotein levels and to elucidate the sex differences in hypertriglyceridemia‐related dietary intake among Japanese individuals. We randomly selected 898 (384 men and 514 women) participants aged 40–78 years in the Gifu Diabetes Study; those taking medication for dyslipidemia or diabetes mellitus were excluded. Serum levels of glucose metabolism parameters and the food frequency were measured cross‐sectionally. The glycated hemoglobin was measured again after 5 years. Glucose metabolism parameters and the percentage of individuals with impaired glucose tolerance were significantly higher in the high triglyceride group in men and women. Similar trends were observed in the low high‐density lipoprotein group, but only in men. Meanwhile, only the homeostasis model assessment of insulin resistance was higher in the high low‐density lipoprotein group. In non‐obese men, the percentage of energy intake from alcohol per total daily energy intake was significantly greater in the high triglyceride group. In obese women, the total energy intake was significantly greater in the high triglyceride group. At the 5‐year follow up, the risk of elevated glycated hemoglobin levels with hypertriglyceridemia was increased in men. Hypertriglyceridemia is a stronger risk factor for impaired glucose tolerance than increased low‐density lipoprotein or decreased high‐density lipoprotein. For dietary habits, increased daily alcohol energy intake in non‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia. Hypertriglyceridemia has a negative effect on glucose metabolism by increasing insulin resistance and secretion. Further, such effect was stronger than hyper‐LDL or lower‐HDL cholesterolemia in the Japanese with dyslipidemia‐induced impaired glucose tolerance. For dietary habits, increased daily alcohol energy intake in non‐obese men and increased total energy intake in obese women were associated with hypertriglyceridemia.
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