Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.
Association between the ENPP1 K121Q polymorphism and risk of diabetic kidney disease: a systematic review and meta-analysis.
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DOI：
10.1371/journal.pone.0118416
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Canani LH
中科院分区：
文献类型：
--
作者：
Sortica DA;Buffon MP;Souza BM;Nicoletto BB;Santer A;Assmann TS;Crispim D;Canani LH
外核苷酸焦磷酸酶/磷酸二酯酶 (ENPP1) 基因中的 K121Q（A/C，rs1044498）多态性与糖尿病肾病 (DKD) 风险之间的潜在关联已得到研究。然而，这种变异对 DKD 风险的影响仍然存在争议，并且已经报道了相互矛盾的结果。迄今为止，尚无荟萃分析评估 K121Q 多态性与 DKD 的关联。本文描述了为评估 ENPP1K121Q 多态性是否与 DKD 相关而进行的首次荟萃分析。我们进行了文献检索，以确定所有评估 ENPP1K121Q 多态性与 DKD 之间关联的病例对照或横断面研究。计算等位基因对比、加性、显性和隐性遗传模型的汇总比值比 (OR) 和 95% 置信区间 (95% CI)。七项研究符合纳入荟萃分析的条件，提供了 3571 名 1 型或 2 型糖尿病患者的数据（1606 名 DKD 病例和 1965 名没有这种并发症的糖尿病对照者）。当假设不同的遗传模型时，荟萃分析中纳入的研究中没有观察到显着的异质性（整个样本的 I² < 50% 或 P > 0.10，并且按种族分层后）。荟萃分析结果显示，假设分析的遗传模型不同，K121Q 多态性与亚洲人和欧洲人的 DKD 风险之间存在显着关联。相加模型观察到最有力的关联（OR = 1.74，总样本的 95% CI 1.27-2.38）。总之，本荟萃分析检测到欧洲和亚洲人群中 ENPP1K121Q 多态性与 DKD 易感性增加之间存在显着关联。
The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism with DKD. This paper describes the first meta-analysis conducted to evaluate whether the ENPP1K121Q polymorphism is associated with DKD. A literature search was conducted to identify all case-control or cross-sectional studies that evaluated associations between the ENPP1K121Q polymorphism and DKD. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant and recessive inheritance models. Seven studies were eligible for inclusion in the meta-analysis, providing data on 3571 type 1 or type 2 diabetic patients (1606 cases with DKD and 1965 diabetic controls without this complication). No significant heterogeneity was observed among the studies included in the meta-analysis when assuming different inheritance models (I² < 50% or P > 0.10 for the entire sample and after stratification by ethnicity). Meta-analysis results revealed significant associations between the K121Q polymorphism and risk of DKD in Asians and Europeans when assuming the different inheritance models analyzed. The most powerful association was observed for the additive model (OR = 1.74, 95% CI 1.27-2.38 for the total sample). In conclusion, the present meta-analysis detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations.
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影响因子：
16.2
作者：
American Diabetes Association
通讯作者：
American Diabetes Association
影响因子：
13.2
作者：
Chen, Guanjie;Adeyemo, Adebowale A.;Rotimi, Charles
通讯作者：
Rotimi, Charles
DOI：
10.1590/s0004-27302010000300002
发表时间：
2010-03-01
期刊：
Arquivos Brasileiros de Endocrinologia & Metabologia
影响因子：
--
作者：
Carpena, Mariana P.;Rados, Dimitris V.;Crispim, Daisy
通讯作者：
Crispim, Daisy
DOI：
10.1053/j.ajkd.2008.07.040
发表时间：
2009-02
期刊：
American journal of kidney diseases : the official journal of the National Kidney Foundation
影响因子：
--
作者：
De Cosmo S;Minenna A;Zhang YY;Thompson R;Miscio G;Vedovato M;Rauseo A;Saller A;Mastroianno S;Pellegrini F;Trevisan R;Fioretto P;Doria A;Trischitta V
通讯作者：
Trischitta V
影响因子：
--
作者：
Berhouma, Rym;Kouidhi, Soumaya;Benammar-Elgaaied, Amel
通讯作者：
Benammar-Elgaaied, Amel