The moderating role of externalizing problems on the association between anxiety and the error-related negativity in youth.
The moderating role of externalizing problems on the association between anxiety and the error-related negativity in youth.
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外部问题在焦虑与青年误差相关的消极情绪之间的关联中的调节作用。
DOI：
10.1002/dev.22023
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发表时间：
2021-05
影响因子：
2.2
通讯作者：
Burkhouse KL
中科院分区：
文献类型：
--
作者：
Suor JH;Granros M;Kujawa A;Fitzgerald KD;Monk CS;Phan KL;Burkhouse KL
与错误相关的负性（ERN）是反映错误监视的与事件相关的电位。增强的ERN表明对表现错误的敏感性，并且与焦虑障碍相关。相比之下，有外化问题的青少年表现出较低的ERN，表明错误监测减少。焦虑和外化问题通常在青少年中同时发生，但没有研究测试共病如何调节ERN。在有或无焦虑障碍的青年样本（N = 46，年龄7-19岁）中，本初步研究考察了焦虑和外化问题对ERN的相互作用。结果提示外化问题调节青少年焦虑症状与ERN的关系。外化问题较少的焦虑青少年对错误的ERN反应增强。相反，外化问题更严重的焦虑青少年在错误反应中表现出更低的ERN。显着区域和比例影响测试表明，外化问题的调节作用仅对患有焦虑症的青少年有显着作用。研究结果表明，增强的神经错误敏感性可能是焦虑症的一种特定的神经生理标志物，而患有共病外化问题的焦虑个体表现出较低的错误监测，与原发性外化病理相似。结果强调了检查小儿焦虑共病亚型的神经相关性的效用。
The error-related negativity (ERN) is an event-related potential that reflects error monitoring. Enhanced ERN indicates sensitivity to performance errors and is a correlate of anxiety disorders. In contrast, youth with externalizing problems exhibit a reduced ERN, suggesting decreased error monitoring. Anxiety and externalizing problems commonly co-occur in youth, but no studies have tested how comorbidity might modulate the ERN. In a sample of youth (N = 46, ages 7-19) with and without anxiety disorders, this preliminary study examined the interactive effect of anxiety and externalizing problems on ERN. Results suggest that externalizing problems moderate the relation between anxiety symptoms and ERN in youth. Anxious youth with less externalizing problems exhibited enhanced ERN response to errors. Conversely, anxious youth with greater externalizing problems demonstrated diminished ERN in response to errors. The regions of significance and proportion affected tests indicated that the moderating effect of externalizing problems was only significant for youth with anxiety disorders. Findings suggest that enhanced neural error sensitivity could be a specific neurophysiological marker for anxiety disorders, whereas anxious individuals with comorbid externalizing problems demonstrate reduced error monitoring, similar to those with primary externalizing pathology. Results underscore the utility of examining neural correlates of pediatric anxiety comorbidity subtypes.
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DOI：
10.1016/j.jaac.2013.09.017
发表时间：
2014-01
影响因子：
13.3
作者：
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