Error-related neural activity and alcohol use disorder: Differences from risk to remission.
Error-related neural activity and alcohol use disorder: Differences from risk to remission.
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DOI：
10.1016/j.pnpbp.2019.01.011
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发表时间：
2019-06-08
影响因子：
5.6
通讯作者：
Shankman SA
中科院分区：
文献类型：
--
作者：
Gorka SM;Lieberman L;Kreutzer KA;Carrillo V;Weinberg A;Shankman SA
研究表明，酒精使用障碍（AUD）患者显示异常的神经错误处理，通过错误相关负性（ERN）测量。然而，由于先前的研究得出了不一致的结果，因此AUD中错误相关异常的性质尚不清楚。此外，迄今为止还没有研究试图描述AUD中ERN的性格特征，并直接测试ERN振幅在多大程度上反映了AUD精神病理学的风险因素、疾病标志物和/或疤痕。本研究比较了以下五组中244名成年志愿者的ERN振幅：1）当前AUD（n=39），2）缓解期AUD（n=60），3）AUD风险组（n=43），4）与Au组内在精神病理学发生率相当的精神对照组（n=53），以及5）无精神病理学终身史的健康对照组（n=49）。AUD风险定义为阳性的一级家族史。所有参与者都完成了一个经过充分验证的侧翼任务，旨在稳健地引出ERN，在连续的脑电图（EEG）数据收集。结果表明，与AUD风险个体、缓解期AUD个体、精神病对照组和健康对照组相比，当前AUD个体的ERN较小。其他组之间无差异。这表明，钝化的ERN可能与当前的AUD精神病理学相关，是一种新的神经生物学AUD治疗靶点和/或AUD疾病状态的客观标志物。
Studies suggest that individuals with alcohol use disorder (AUD) display abnormal neural error-processing, measured via the error-related negativity (ERN). The nature of the error-related abnormalities in AUD is unclear, however, as prior research has yielded discrepant findings. In addition, no study to date has attempted to characterize the dispositional nature of the ERN in AUD and directly test to what extent ERN amplitude reflects a risk factor, disease marker, and/or scar of AUD psychopathology. The current study compared ERN amplitude across 244 adult volunteers in the following five groups: 1) current AUD (n=39), 2) AUD in remission (n=60), 3) at-risk for AUD (n=43), 4) psychiatric controls with comparable rates of internalizing psychopathology as the AU groups (n=53), and 5) healthy controls with no lifetime history of psychopathology (n=49). Risk for AUD was defined as a positive, first-degree family history. All participants completed a well-validated flanker task, designed to robustly elicit the ERN, during continuous electroencephalographic (EEG) data collection. Results indicated that individuals with current AUD displayed smaller ERNs compared with individuals at-risk for AUD, with AUD in remission, psychiatric controls, and healthy controls. There were no differences amongst any of the other groups. This suggests that a blunted ERN may be concomitant with current AUD psychopathology and relatedly, a novel neurobiological AUD treatment target and/or objective marker of AUD disease status.
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