Obesity, high-molecular-weight (HMW) adiponectin, and metabolic risk factors: prevalence and gender-specific associations in Estonia.
Obesity, high-molecular-weight (HMW) adiponectin, and metabolic risk factors: prevalence and gender-specific associations in Estonia.
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DOI：
10.1371/journal.pone.0073273
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lember M
中科院分区：
文献类型：
--
作者：
Eglit T;Ringmets I;Lember M
肥胖的代谢后果与脂肪细胞因子（如脂联素）的失衡有关。然而，一些肥胖受试者的代谢保持健康，其脂联素水平与正常体重的受试者相似。目前对爱沙尼亚肥胖流行程度的估计仅依赖于自我报告的数据。评估爱沙尼亚肥胖的流行程度，测试HMW脂联素与代谢危险因素之间的关联，并测试HMW脂联素水平是否能区分代谢健康和代谢不健康的受试者。我们进行了一项以人群为基础的横断面多中心研究，收集了495名年龄在20-74岁的受试者的病史、检查和血液测试结果。代谢健康的受试者没有高血压、血脂异常、血糖调节障碍和胰岛素抵抗。代谢不健康的受试者至少有这四种代谢异常中的一种。男性和女性的肥胖率分别为29%和34%。HMW脂联素与HDL胆固醇呈正相关，与甘油三酯、肥胖、胰岛素抵抗、血糖呈负相关。这种效应是由代谢不健康的男性受试者驱动的，但同时由代谢健康和代谢不健康的女性受试者驱动。代谢健康的女性HMW脂联素水平高于代谢不健康的女性。12%的肥胖受试者代谢健康，他们的HMW脂联素水平与正常体重的受试者相似。肥胖在爱沙尼亚成年人中比以前认为的更为普遍。在代谢健康的女性中，HMW脂联素水平与各种代谢危险因素相关，而在代谢健康的男性中则无关。对于两性，HMW脂联素可以区分代谢健康的肥胖受试者和代谢不健康的肥胖受试者。
The metabolic consequences of obesity are associated with an imbalance of adipocytokines, e.g. adiponectin. However, some obese subjects remain metabolically healthy and have adiponectin levels similar to normal body weight subjects. Current estimates of the prevalence of obesity in Estonia have relied only on self-report data. To estimate the prevalence of obesity in Estonia, to test for associations between HMW adiponectin and metabolic risk factors and to test if HMW adiponectin levels differentiate metabolically healthy and metabolically unhealthy subjects. We conducted a population-based cross-sectional multicentre study to gather history, examination and blood test results for 495 subjects aged 20–74. Metabolically healthy subjects were free from hypertension, dyslipidaemia, impaired glucose regulation and insulin resistance. Metabolically unhealthy subjects had at least one of these four metabolic abnormalities. The prevalence of obesity was 29% in men and 34% in women. HMW adiponectin was positively correlated with HDL cholesterol and negatively correlated with triglycerides, obesity, insulin resistance and blood glucose. This effect was driven by metabolically unhealthy subjects in men, but by both metabolically healthy and metabolically unhealthy subjects in women. Metabolically healthy women had higher HMW adiponectin levels than metabolically unhealthy women. 12% of all obese subjects were metabolically healthy, and their HMW adiponectin levels were similar to normal weight subjects. Obesity is more prevalent in Estonian adults than previously thought. HMW adiponectin levels were associated with various metabolic risk factors in metabolically healthy women but not in metabolically healthy men. For both genders, HMW adiponectin differentiates metabolically healthy obese subjects from metabolically unhealthy obese subjects.
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