Oleic Acid Alleviates Cadmium-Induced Oxidative Damage in Rat by Its Radicals Scavenging Activity
Oleic Acid Alleviates Cadmium-Induced Oxidative Damage in Rat by Its Radicals Scavenging Activity
复制标题
油酸通过其自由基清除活性减轻镉引起的大鼠氧化损伤
DOI：
10.1007/s12011-018-1526-4
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发表时间：
2018-09
影响因子：
3.9
通讯作者：
Gooneratne R
中科院分区：
文献类型：
--
作者：
Wang J;Zhang Y;Fang Z;Sun L;Wang Y;Liu Y;Xu D;Nie F;Gooneratne R
有毒重金属镉严重污染环境，威胁人类健康。有效治疗镉引起的毒性和器官损伤是一个重要问题。镉通过诱导氧化应激造成器官损伤。我们前期的研究还发现油酸（OA）合成相关基因可以赋予酵母对镉的抗性，减轻镉引起的应激。然而，其对镉应激尤其是动物体内镉应激的缓解机制仍不清楚。在这项研究中，研究了OA对镉和镉诱导的大鼠氧化应激的缓解作用。连续7天腹腔注射30 mg/kg/天镉的大鼠，口服10、20和30 mg/kg/天的OA可显着提高大鼠的存活率。与抗坏血酸（AA）相似，OA可以显着降低镉诱导的大鼠多个器官的脂质过氧化。 OA 对超氧化物歧化酶 (SOD) 活性的研究表明，OA 增加了镉处理的大鼠器官的 SOD 活性。更重要的是，OA 降低了镉处理的大鼠器官的超氧自由基 O2− 水平。 OA 在 10、20 和 30 mg/mL 的剂量下表现出很强的 DPPH 自由基清除活性，这可能有助于缓解镉诱导的氧化应激。这项研究表明，OA 可以通过减少镉诱导的脂质过氧化和自由基清除活性抑制 SOD 活性来显着缓解镉应激。
Toxic heavy metal cadmium wildly pollutes the environment and threats the human health. Effective treatment of cadmium-induced toxicity and organ damage is an important issue. Cadmium causes organ damage through inducing oxidative stress. Our previous study also found oleic acid (OA) synthesis-related gene can confer resistance to cadmium and alleviate cadmium-induced stress in yeast. However, its alleviation mechanism on cadmium stress especially in animals is still unclear. In this study, the alleviative effects of OA on cadmium and cadmium-induced oxidative stress in rats were investigated. Oral administration of 10, 20, and 30 mg/kg/day OA can significantly increase the survival rate of rats intraperitoneally injected with 30 mg/kg/day cadmium continuously for 7 days. Similar to ascorbic acid (AA), OA can significantly reduce the cadmium-induced lipid peroxidation in multiple organs of rats. The investigation of OA on superoxide dismutase (SOD) activity showed that OA increased the SOD activity of cadmium-treated rat organs. More important, OA reduced the level of superoxide radical O2−of cadmium-treated rat organs. And OA exhibited a strong DPPH radicals scavenging activity at dose of 10, 20 and 30 mg/mL, which may contributed to alleviating cadmium-induced oxidative stress. This study revealed that OA could significantly alleviate cadmium stress via reducing cadmium-induced lipid peroxidation and SOD activity inhibition through its radicals scavenging activity.
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影响因子：
3.9
作者：
S. Karaca;G. Eraslan
通讯作者：
S. Karaca;G. Eraslan
DOI：
10.1007/978-3-662-07743-6_5
发表时间：
2004
期刊：
--
影响因子：
--
作者：
S. Rama Devi;M. N. V. Prasad
通讯作者：
S. Rama Devi;M. N. V. Prasad
DOI：
10.1006/niox.2000.0295
发表时间：
2000-08
期刊：
Nitric oxide : biology and chemistry
影响因子：
--
作者：
S. Satarug;J. R. Baker;Paul E.B. Reilly;Hiroyasu Esumi;Michael R. Moore
通讯作者：
S. Satarug;J. R. Baker;Paul E.B. Reilly;Hiroyasu Esumi;Michael R. Moore
影响因子：
2.6
作者：
S. Jamilaldine Fatemi;S. Tubafard;B. Nadi
通讯作者：
S. Jamilaldine Fatemi;S. Tubafard;B. Nadi
影响因子：
5.2
作者：
Nouairi, I;Ben Ammar, W;Zarrouk, M
通讯作者：
Zarrouk, M