The effects of memory training on behavioral and microstructural plasticity in young and older adults.
The effects of memory training on behavioral and microstructural plasticity in young and older adults.
复制标题
DOI：
10.1002/hbm.23756
复制
发表时间：
2017-11
影响因子：
4.8
通讯作者：
Walhovd KB
中科院分区：
文献类型：
--
作者：
de Lange AG;Bråthen ACS;Rohani DA;Grydeland H;Fjell AM;Walhovd KB
人类大脑可塑性的年龄差异是假设的，但尚未进行系统的研究。在这项纵向研究中，我们调查了183名年轻人和老年人在被动和主动控制条件下进行记忆训练时白质（WM）微结构的变化。我们假设：(1)只有训练组会表现出记忆性能的改善和微观结构的改变，(2)与老年人相比，年轻人会表现出更大的记忆改善和更高程度的微观结构改变，(3)记忆性能的变化与微观结构的改变有关。结果显示，记忆力的改善是训练组特有的，年轻和年长的参与者都提高了他们的表现。与老年组相比，年轻组的记忆力得到了更大程度的改善。在年龄较大的样本中，与对照组相比，训练组在胼胝体、皮质脊髓束、扣带束、上纵束和丘脑前辐射重叠区域的WM微结构显示出较少的与年龄相关的下降。更少的微观结构衰退与更高程度的记忆改善有关。尽管个体适应确保了足够的任务难度，但在年轻人中没有发现与训练相关的微观结构组差异。观察到的行为和微观结构对记忆训练的反应随年龄的差异在供需框架内进行了讨论。研究结果表明，这种可塑性一直保持到老年，微观结构的改变可能是老年人行为改善的神经生物学基础的一部分。中国生物医学工程学报（英文版），2017。©2018作者人脑图谱由wiley期刊公司出版。
Age differences in human brain plasticity are assumed, but have not been systematically investigated. In this longitudinal study, we investigated changes in white matter (WM) microstructure in response to memory training relative to passive and active control conditions in 183 young and older adults. We hypothesized that (i) only the training group would show improved memory performance and microstructural alterations, (ii) the young adults would show larger memory improvement and a higher degree of microstructural alterations as compared to the older adults, and (iii) changes in memory performance would relate to microstructural alterations. The results showed that memory improvement was specific to the training group, and that both the young and older participants improved their performance. The young group improved their memory to a larger extent compared to the older group. In the older sample, the training group showed less age‐related decline in WM microstructure compared to the control groups, in areas overlapping the corpus callosum, the cortico‐spinal tract, the cingulum bundle, the superior longitudinal fasciculus, and the anterior thalamic radiation. Less microstructural decline was related to a higher degree of memory improvement. Despite individual adaptation securing sufficient task difficulty, no training‐related group differences in microstructure were found in the young adults. The observed divergence of behavioral and microstructural responses to memory training with age is discussed within a supply‐demand framework. The results demonstrate that plasticity is preserved into older age, and that microstructural alterations may be part of a neurobiological substrate for behavioral improvements in older adults. Hum Brain Mapp 38:5666–5680, 2017. © 2018 The Authors Human Brain Mapping Published byWiley Periodicals, Inc.
登录
查看更多内容
影响因子：
3.7
作者：
Blumenfeld-Katzir T;Pasternak O;Dagan M;Assaf Y
通讯作者：
Assaf Y
影响因子：
120.7
作者：
Ball, K;Berch, DB;Willis, SL
通讯作者：
Willis, SL
影响因子：
5.7
作者：
Barrick, Thomas R.;Charlton, Rebecca A.;Markus, Hugh S.
通讯作者：
Markus, Hugh S.
影响因子：
5.3
作者：
Boyke, Janina;Driemeyer, Joenna;May, Arne
通讯作者：
May, Arne
影响因子：
3.5
作者：
Bailey, Heather R.;Dunlosky, John;Hertzog, Christopher
通讯作者：
Hertzog, Christopher