Bifunctional MXene-Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration.
Bifunctional MXene-Augmented Retinal Progenitor Cell Transplantation for Retinal Degeneration.
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DOI：
10.1002/advs.202302747
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发表时间：
2023-09
期刊：
影响因子：
15.1
通讯作者：
Gu, Ping
中科院分区：
文献类型：
--
作者：
Tang, Zhimin;Liu, Yan;Xiang, Huijing;Dai, Xinyue;Huang, Xiaolin;Ju, Yahan;Ni, Ni;Huang, Rui;Gao, Huiqin;Zhang, Jing;Fan, Xianqun;Su, Yun;Chen, Yu;Gu, Ping
关键词：
视网膜变性以视网膜神经元逐渐丧失为特征，是导致无法治愈的视力障碍的主要原因。基于视网膜祖细胞（RPC）的移植可以促进视力恢复，但该过程的临床疗效受到RPC不精确的神经源性分化以及破坏被严重氧化性视网膜病变包围的移植细胞的功能的影响。研究表明，超薄碳化铌 (Nb2C) MXene 能够增强 RPC 的视网膜再生性能。具有中等光热效应的Nb2C MXene除了通过同时清除自由基来高效保护RPC外，还通过激活细胞内信号传导显着改善RPC的视网膜神经元分化，这已得到综合生物医学评估和理论计算的有力证明。将 MXene 辅助的 RPC 视网膜下移植到典型的视网膜变性 10 (rd10) 小鼠中后，观察到神经元分化显着增加，从而有助于视网膜结构和视觉功能的有效恢复。 MXene 的双重内在功能协同辅助 RPC 移植，这代表了视力恢复研究领域的一个有趣的范例，并将拓宽纳米医学的多功能视野。具有中等光热效应和高生物相容性的强效自由基清除碳化铌（Nb2C）MXene可增强视网膜祖细胞（RPC）治疗视网膜变性的性能。合成的Nb2C MXene不仅可以引导RPC优先分化为视网膜神经元谱系，而且根据系统的生物学评估和理论计算，可以大幅降低自由基水平，最终挽救视网膜结构并保留视觉功能。
Retinal degeneration, characterized by the progressive loss of retinal neurons, is the leading cause of incurable visual impairment. Retinal progenitor cells (RPCs)‐based transplantation can facilitate sight restoration, but the clinical efficacy of this process is compromised by the imprecise neurogenic differentiation of RPCs and undermining function of transplanted cells surrounded by severely oxidative retinal lesions. Here, it is shown that ultrathin niobium carbide (Nb2C) MXene enables performance enhancement of RPCs for retinal regeneration. Nb2C MXene with moderate photothermal effect markedly improves retinal neuronal differentiation of RPCs by activating intracellular signaling, in addition to the highly effective RPC protection by scavenging free radicals concurrently, which has been solidly evidenced by the comprehensive biomedical assessments and theoretical calculations. A dramatically increased neuronal differentiation is observed upon subretinal transplantation of MXene‐assisted RPCs into the typical retinal degeneration 10 (rd10) mice, thereby contributing to the efficient restoration of retinal architecture and visual function. The dual‐intrinsic function of MXene synergistically aids RPC transplantation, which represents an intriguing paradigm in vision‐restoration research filed, and will broaden the multifunctionality horizon of nanomedicine. Potent‐free radical‐scavenging niobium carbide (Nb2C) MXene with moderate photothermal effect and high biocompatibility enhances the performance of retinal progenitor cells (RPCs) for retinal degeneration. The synthetic Nb2C MXene can not only direct RPC preferentially differentiate into retinal neuronal lineages, but also substantially reduce the free‐radical levels based on systematically biological evaluations and theoretical calculations, eventually rescuing retinal structure and preserving visual function.
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