The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell.
The basolateral amygdala differentially regulates conditioned neural responses within the nucleus accumbens core and shell.
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DOI：
10.1016/j.neuroscience.2010.05.073
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发表时间：
2010-09-01
期刊：
影响因子：
3.3
通讯作者：
Carelli, R. M.
中科院分区：
文献类型：
--
作者：
Jones, J. L.;Day, J. J.;Wheeler, R. A.;Carelli, R. M.
处理有关奖励预测线索的信息的能力涉及不同的神经基质网络。鉴于伏隔核（NAc）和基底外侧杏仁核（BLA）在联想奖励过程中的重要性，最近的研究考察了BLA-NAc相互作用的功能重要性。本研究采用NAc神经元的多神经元细胞外记录，并将GABAA和GABAB激动剂微量注入到BLA中，以确定在提示仪器任务中，BLA对NAc核和壳的相性神经活动的功能贡献。在BLA失活之前，NAc神经反应谱在核心和壳层上表现出难以区分的活性。然而，对于在任务期间表现出与线索相关的放电率增加的NAc神经元，BLA失活显著地选择性地减少了核心（而不是外壳）的这种活性。此外，在杠杆按压反应后，核心（而非壳）射击速率的阶段性增加也在BLA操作后显着减少。与这些神经变化同时发生的是，BLA的失活导致对奖励的反应延迟显著增加，并减少了动物对提示做出条件反射的实验百分比。综上所述，这些结果表明，在提示工具任务中，BLA的兴奋性投射为NAc核心神经元的条件神经兴奋提供了选择性贡献，从而深入了解了介导对奖励预测线索反应的潜在神经回路。
The ability to process information regarding reward-predictive cues involves a diverse network of neural substrates. Given the importance of the nucleus accumbens (NAc) and the basolateral amygdala (BLA) in associative reward processes, recent research has examined the functional importance of BLA-NAc interactions. Here, multi-neuron extracellular recordings of NAc neurons coupled to microinfusion of GABAA and GABAB agonists into the BLA were employed to determine the functional contribution of the BLA to phasic neural activity across the NAc core and shell during a cued-instrumental task. NAc neural response profiles prior to BLA inactivation exhibited largely indistinguishable activity across the core and shell. However, for NAc neurons that displayed cue-related increases in firing rates during the task, BLA inactivation significantly reduced this activity selectively in the core (not shell). Additionally, phasic increases in firing rate in the core (not shell) immediately following the lever press response were also significantly reduced following BLA manipulation. Concurrent with these neural changes, BLA inactivation caused a significant increase in latency to respond for rewards and a decrease in the percentage of trials in which animals made a conditioned approach to the cue. Together, these results suggest that an excitatory projection from the BLA provides a selective contribution to conditioned neural excitations of NAc core neurons during a cued-instrumental task, providing insight into the underlying neural circuitry that mediates responding to reward-predictive cues.
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