Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection.
Chronic exercise reduces illness severity, decreases viral load, and results in greater anti-inflammatory effects than acute exercise during influenza infection.
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DOI：
10.1086/606014
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发表时间：
2009-11-01
期刊：
影响因子：
--
通讯作者：
Kohut ML
中科院分区：
文献类型：
--
作者：
Sim YJ;Yu S;Yoon KJ;Loiacono CM;Kohut ML
人们认为，适度的运动可以提高对感染的抵抗力并减少炎症，但在感染模型中支持这一假设的数据有限。将BALB/cJ小鼠分配到以下组：不运动（NON-EX）、1次急性运动（A-EX）或慢性运动约3.5个月（C-EX）。用流感病毒感染小鼠（C-EX小鼠在休息时感染; A-EX小鼠在运动后15分钟感染）。C-EX小鼠表现出最低的感染严重程度，通过体重减轻和食物摄入来评估。与NON-EX小鼠相比，C-EX和A-EX小鼠在感染后第5天的肺部病毒较少（P = 0.02），并且仅在C-EX小鼠中在感染后第2天的病毒较少（P = 0.07）。感染后不久（第2天），C-EX和A-EX小鼠支气管肺泡灌洗液（BAL）中的白细胞介素6（IL-6）、单核细胞趋化蛋白1（MCP-1）、巨噬细胞炎性蛋白1 β和肿瘤坏死因子α低于NON-EX小鼠。在感染后第5天，来自C-EX（而不是A-EX）小鼠的BAL液具有比来自NON-EX小鼠的更少的IL-6、白细胞介素12p40、粒细胞集落刺激因子、角质形成细胞衍生的趋化因子和MCP-1。在C-EX小鼠中发现了免疫病理学应答降低的趋势。慢性运动导致症状减轻，病毒载量减少，炎症细胞因子和趋化因子水平降低。急性运动也显示出一定的益处，但仅限于感染的早期阶段。
It is assumed that moderate exercise may improve resistance to infection and reduce inflammation, but there are limited data to support this assumption in an infection model. BALB/cJ mice were assigned to the following groups: no exercise (NON-EX), 1 session of acute exercise (A-EX), or chronic exercise for ~3.5 months (C-EX). Mice were infected with influenza (C-EX mice infected at rest; A-EX mice infected 15 min after exercise). C-EX mice demonstrated the lowest severity of infection, assessed by body weight loss and food intake. There was less virus in the lungs at day 5 after infection in C-EX and A-EX mice compared with NON-EX mice (P = .02) and less virus at day 2 after infection only in C-EX mice (P = .07). Soon after infection (day 2), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1β, and tumor necrosis factor α in the bronchoalveolar lavage (BAL) fluid were lower in C-EX and A-EX than in NON-EX mice. At day 5 after infection, the BAL fluid from C-EX (but not A-EX) mice had less IL-6, interleukin 12p40, granulocyte colony-stimulating factor, keratinococyte-derived chemokine, and MCP-1 than that from NON-EX mice. A trend toward reduced immunopathologic response was found in C-EX mice. Chronic exercise resulted in reduced symptoms, virus load, and levels of inflammatory cytokine and chemokines. Acute exercise also showed some benefit, which was limited to the early phase of infection.
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影响因子：
13.6
作者：
KIEL, RJ;SMITH, FE;REYES, MP
通讯作者：
REYES, MP
影响因子：
5.8
作者：
Hartshorn, Kevan L.;White, Mitchell R.;Holmskov, Uffe
通讯作者：
Holmskov, Uffe
DOI：
10.1097/00005768-200208000-00003
发表时间：
2002-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Matthews, CE;Ockene, IS;Hebert, JR
通讯作者：
Hebert, JR
影响因子：
15.1
作者：
Murphy, E. A.;Davis, J. M.;Mayer, E. P.
通讯作者：
Mayer, E. P.
影响因子：
5.4
作者：
Benne, CA;BenaissaTrouw, B;vanIwaarden, JFF
通讯作者：
vanIwaarden, JFF