Phase delaying the human circadian clock with blue-enriched polychromatic light.
Phase delaying the human circadian clock with blue-enriched polychromatic light.
复制标题
DOI：
10.1080/07420520902927742
复制
发表时间：
2009-05
影响因子：
2.8
通讯作者：
Eastman CI
中科院分区：
文献类型：
--
作者：
Smith MR;Eastman CI
人类昼夜节律系统对短波长（蓝色）光最敏感。在之前的一项研究中，我们发现在可用于现实世界的实用协议中使用灯箱的亮白光与亮蓝光增强光产生的相位超前幅度没有差异。由于昼夜节律系统的光谱敏感性可能随昼夜节律而变化，我们测试了我们最近的相位提前研究的结果是否适用于相位延迟。在受试者体内平衡设计中，本研究测试了明亮的富含蓝色的多色光（17000 K，4000 lux）是否可以比相同光子密度（4.2 × 1015 光子/cm2/秒）的明亮白光（4100 K，5000 lux）产生更大的相位延迟。健康的年轻受试者 (n = 13) 在睡前接受 2 小时相位延迟光脉冲，并在连续 4 个治疗日的每一天接受逐渐延迟的睡眠/黑暗时间表。在第一个治疗日，在弱光褪黑激素作用 (DLMO) 后 3 小时开始光脉冲。光脉冲结束时开始 8 小时的睡眠。光照治疗和睡眠时间表在随后的每个治疗日推迟 2 小时。在一系列光治疗日之前和之后进行昼夜节律阶段评估，以确定 DLMO 和 DLMOff 的时间。富含蓝色和白色条件下的相位延迟没有显着差异（DLMO：分别为-4.45±2.02与-4.48±1.97小时；DLMOff：-3.90±1.97与-4.35±2.39小时）。这些结果表明，在通常用于昼夜节律相移的光水平下，富蓝色多色光对于生物钟相位延迟并不比相关色温（CCT）较低的白色多色灯更有效。
The human circadian system is maximally sensitive to short-wavelength (blue) light. In a previous study we found no difference between the magnitude of phase advances produced by bright white versus bright blue-enriched light using light boxes in a practical protocol that could be used in the real world. Since the spectral sensitivity of the circadian system may vary with a circadian rhythm, we tested whether the results of our recent phase-advancing study hold true for phase delays. In a within-subjects counterbalanced design, this study tested whether bright blue-enriched polychromatic light (17000 K, 4000 lux) could produce larger phase delays than bright white light (4100 K, 5000 lux) of equal photon density (4.2 × 1015 photons/cm2/sec). Healthy young subjects (n = 13) received a 2 h phase delaying light pulse before bedtime combined with a gradually delaying sleep/dark schedule on each of 4 consecutive treatment days. On the first treatment day the light pulse began 3 h after the dim light melatonin onset (DLMO). An 8 h sleep episode began at the end of the light pulse. Light treatment and the sleep schedule were delayed 2 h on each subsequent treatment day. A circadian phase assessment was conducted before and after the series of light treatment days to determine the time of the DLMO and DLMOff. Phase delays in the blue-enriched and white conditions were not significantly different (DLMO: −4.45 ± 2.02 versus −4.48 ± 1.97 h; DLMOff: −3.90 ± 1.97 versus −4.35 ± 2.39 h, respectively). These results indicate that at light levels commonly used for circadian phase shifting blue-enriched polychromatic light is no more effective than the white polychromatic lamps of a lower correlated color temperature (CCT) for phase delaying the circadian clock.
登录
查看更多内容
影响因子：
2.4
作者：
Bierman, A;Klein, TR;Rea, MS
通讯作者：
Rea, MS
影响因子：
2.5
作者：
Figueiro, Mariana G.;Rea, Mark S.;Bullough, John D.
通讯作者：
Bullough, John D.
影响因子：
1.1
作者：
Lack, Leon;Bramwell, Toby;Kemp, Kristyn
通讯作者：
Kemp, Kristyn
影响因子：
2.8
作者：
Portaluppi, Francesco;Touitou, Yvan;Smolensky, Michael H.
通讯作者：
Smolensky, Michael H.
影响因子：
5.8
作者：
Lockley, SW;Brainard, GC;Czeisler, CA
通讯作者：
Czeisler, CA