Subnormal peripheral blood leukocyte counts are related to the lowest prevalence and incidence of metabolic syndrome: Tianjin chronic low-grade systemic inflammation and health cohort study.
Subnormal peripheral blood leukocyte counts are related to the lowest prevalence and incidence of metabolic syndrome: Tianjin chronic low-grade systemic inflammation and health cohort study.
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DOI：
10.1155/2014/412386
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发表时间：
2014
影响因子：
4.6
通讯作者：
Niu K
中科院分区：
文献类型：
--
作者：
Sun S;Wu H;Zhang Q;Wang C;Guo Y;Du H;Liu L;Jia Q;Wang X;Song K;Niu K
很少有研究评估亚正常炎症状态和代谢综合征（MS）之间的关系。因此，我们设计了一个横断面和5年的队列研究，以评估外周血白细胞计数低于正常是如何与MS。参与者从天津医科大学总医院健康管理中心招募。进行了基线横断面（n = 46，179）和前瞻性评估（n = 13，061）。没有MS病史的参与者随访5年。在基线和随访期间每年评估白细胞计数和MS组分。校正的逻辑和考克斯比例风险回归模型用于评估白细胞计数类别和MS之间的关系。（1100 -3，900个细胞/mm 3）的MS患病率和发病率最低。最高白细胞计数（95%置信区间）为1.98（1.57-2.49）和1.50（1.22-1.84）（趋势P均<0.0001）。这项研究表明，白细胞计数低于正常是独立相关的MS的患病率和发病率最低的研究结果表明，有必要重新研究和讨论的临床或预防价值的白细胞计数低于正常。
Few studies have assessed the relationship between a subnormal inflammatory status and metabolic syndrome (MS). We therefore designed a cross-sectional and 5-year cohort study to evaluate how a subnormal peripheral blood leukocyte count is related to MS. Participants were recruited from Tianjin Medical University General Hospital-Health Management Centre. Both a baseline cross-sectional (n = 46,179) and a prospective assessment (n = 13,061) were performed. Participants without a history of MS were followed up for 5 years. Leukocyte counts and MS components were assessed at baseline and yearly during the follow-up. Adjusted logistic and Cox proportional hazards regression models were used to assess relationships between the categories of leukocyte counts and MS. The subnormal leukocyte counts group (1,100–3,900 cells/mm3) had the lowest prevalence and incidence of MS. The odds ratio and hazard ratio (95% confidence interval) of the highest leukocyte counts were 1.98 (1.57–2.49) and 1.50 (1.22–1.84) (both P for trend <0.0001), respectively, when compared to the subnormal leukocyte counts group after adjusting for potential confounders. This study has shown that subnormal leukocyte counts are independently related to the lowest prevalence and incidence of MS. The findings suggest that it is necessary to restudy and discuss the clinical or preventive value of subnormal leukocyte counts.
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影响因子：
1.3
作者：
Hsu, Wen-Yin;Wu, Cheng-Hsuan;Kao, Mei-Ding
通讯作者：
Kao, Mei-Ding
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
影响因子：
37.8
作者：
Pearson, TA;Mensah, GA;Vinicor, F
通讯作者：
Vinicor, F
DOI：
10.1097/mco.0b013e32833aab7f
发表时间：
2010-07-01
影响因子：
3.1
作者：
Sell, Henrike;Eckel, Juergen
通讯作者：
Eckel, Juergen
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.