Intrinsic and task-dependent coupling of neuronal population activity in human parietal cortex.
Intrinsic and task-dependent coupling of neuronal population activity in human parietal cortex.
复制标题
DOI：
10.1016/j.neuron.2015.03.018
复制
发表时间：
2015-04-22
期刊：
影响因子：
16.2
通讯作者：
Parvizi, Josef
中科院分区：
文献类型：
--
作者：
Foster, Brett L.;Rangarajan, Vinitha;Shirer, William R.;Parvizi, Josef
人类神经影像学研究表明，内侧和外侧顶叶皮层的子区域形成了支持情景记忆检索的更大大脑网络的关键节点。为了探索这些子区域之间功能连接的电生理相关性，我们使用颅内电极对三名受试者同时记录内侧和外侧顶叶皮层。我们在高频宽带（HFB 或高伽玛）范围内观察到压后/后扣带皮层 (RSC/PCC) 和角回 (AG) 的电生理共同激活，适用于需要情景检索的情况。在休息和睡眠状态下，HFB 活动的缓慢波动（< 1 Hz）在这些任务共同激活的神经元群体之间高度相关。此外，内在的电生理连接模式与同一受试者的静息态功能磁共振成像（fMRI）获得的模式相匹配。我们的研究结果量化了情景记忆检索过程中顶叶皮层的时空动态，并提供了人脑内在和任务依赖性功能连接的清晰的神经生理学相关性。
Human neuroimaging studies have suggested that subregions of the medial and lateral parietal cortex form key nodes of a larger brain network supporting episodic memory retrieval. To explore the electrophysiological correlates of functional connectivity between these subregions, we recorded simultaneously from medial and lateral parietal cortex using intracranial electrodes in three human subjects. We observed electrophysiological co-activation of retrosplenial/posterior cingulate cortex (RSC/PCC) and angular gyrus (AG) in the high frequency broadband (HFB, or high-gamma) range, for conditions that required episodic retrieval. During resting and sleeping states, slow fluctuations (< 1 Hz) of HFB activity were highly correlated between these task-co-activated neuronal populations. Furthermore, intrinsic electrophysiological connectivity patterns matched those obtained with resting state functional magnetic resonance imaging (fMRI) from the same subjects. Our findings quantify the spatiotemporal dynamics of parietal cortex during episodic memory retrieval and provide clear neurophysiological correlates of intrinsic and task-dependent functional connectivity in the human brain.
登录
查看更多内容
DOI：
10.1523/jneurosci.2041-09.2009
发表时间：
2009-10-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Manning JR;Jacobs J;Fried I;Kahana MJ
通讯作者：
Kahana MJ
影响因子：
5.3
作者：
Foster, Brett L.;Kaveh, Anthony;Parvizi, Josef
通讯作者：
Parvizi, Josef
影响因子：
5.7
作者：
Foster, Brett L.;Parvizi, Josef
通讯作者：
Parvizi, Josef
影响因子：
2.5
作者：
Kobayashi, Yasushi;Amaral, David G.
通讯作者：
Amaral, David G.
影响因子：
16.2
作者：
Fisch, Lior;Privman, Eran;Ramot, Michal;Harel, Michal;Nir, Yuval;Kipervasser, Svetlana;Andelman, Fani;Neufeld, Miri Y.;Kramer, Uri;Fried, Itzhak;Malach, Rafael
通讯作者：
Malach, Rafael