What can we learn from brain autopsies in COVID-19?
What can we learn from brain autopsies in COVID-19?
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DOI：
10.1016/j.neulet.2020.135528
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发表时间：
2021-01-18
影响因子：
2.5
通讯作者：
Solomon IH
中科院分区：
文献类型：
--
作者：
Mukerji SS;Solomon IH
COVID-19脑尸检中存在慢性神经系统疾病和急性异常。经常观察到急性缺氧性损伤、出血和轻微炎症。存在低水平的病毒SARS-CoV-2 RNA;细胞来源仍然未知。严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是2019年冠状病毒病（COVID-19）的病原体，全球已确诊5000多万例，死亡120万例。虽然许多SARS-CoV-2感染者没有症状或出现呼吸道症状，但肺外表现，包括神经系统症状和状况，越来越多地被认识到。对于COVID-19神经系统症状的潜在机制以及SARS-CoV-2是否具有人类神经侵袭的潜力仍然没有明确的了解。在这篇简短的综述中，我们讨论了从致命的COVID-19的人类尸检中所了解的情况，包括强调调查SARS-CoV-2在大脑和嗅觉组织中存在的研究，并总结了感染的神经病理学后果。将脑组织的显微镜和分子发现转化为我们对临床疾病的了解，将为最佳实践管理指导和直接研究优先事项提供信息，因为它与COVID-19的神经系统发病率有关。
Chronic neurological disease and acute abnormalities are present in COVID-19 brain autopsies. Acute hypoxic-injury, hemorrhage, and minimal inflammation are frequently observed. Low levels of viral SARS-CoV-2 RNA are present; cellular source remains unknown. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19) for which there have been over 50 million confirmed cases and 1.2 million deaths globally. While many SARS-CoV-2 infected individuals are asymptomatic or experience respiratory symptoms, extrapulmonary manifestations, including neurological symptoms and conditions, are increasingly recognized. There remains no clear understanding of the mechanisms that underlie neurological symptoms in COVID-19 and whether SARS-CoV-2 has the potential for neuroinvasion in humans. In this minireview, we discuss what is known from human autopsies in fatal COVID-19, including highlighting studies that investigate for the presence of SARS-CoV-2 in brain and olfactory tissue, and summarize the neuropathological consequences of infection. Incorporating microscopic and molecular findings from brain tissue into what we know about clinical disease will inform best practice management guidance and direct research priorities as it relates to neurological morbidity from COVID-19.
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DOI：
10.1016/s1474-4422(20)30308-2
发表时间：
2020-11
期刊：
The Lancet. Neurology
影响因子：
--
作者：
Matschke J;Lütgehetmann M;Hagel C;Sperhake JP;Schröder AS;Edler C;Mushumba H;Fitzek A;Allweiss L;Dandri M;Dottermusch M;Heinemann A;Pfefferle S;Schwabenland M;Sumner Magruder D;Bonn S;Prinz M;Gerloff C;Püschel K;Krasemann S;Aepfelbacher M;Glatzel M
通讯作者：
Glatzel M
影响因子：
28.3
作者：
Gorbalenya, Alexander E.;Baker, Susan C.;Ziebuhr, John
通讯作者：
Ziebuhr, John
影响因子：
12.7
作者：
Jaunmuktane, Zane;Mahadeva, Ula;Brandner, Sebastian
通讯作者：
Brandner, Sebastian
影响因子：
1.1
作者：
Craver, Randall;Huber, Samantha;Finger, Leron
通讯作者：
Finger, Leron
影响因子：
105.7
作者：
Docherty, Annemarie B.;Harrison, Ewen M.;Semple, Malcolm G.
通讯作者：
Semple, Malcolm G.