Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers.
Circulating microRNAs in breast cancer: novel diagnostic and prognostic biomarkers.
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DOI：
10.1038/cddis.2017.440
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发表时间：
2017-09-07
影响因子：
9
通讯作者：
Alajez NM
中科院分区：
文献类型：
--
作者：
Hamam R;Hamam D;Alsaleh KA;Kassem M;Zaher W;Alfayez M;Aldahmash A;Alajez NM
乳腺癌的有效管理取决于早期诊断和适当监测患者对治疗的反应。然而，由于缺乏用于早期检测和疾病监测的敏感和特异性生物标志物，这些目标难以实现。在过去几年中积累的证据已经突出了外周血循环核酸如DNA、mRNA和微（mi）RNA在乳腺癌诊断、预后和用于监测对抗癌治疗的反应中的潜在用途。其中，循环miRNA越来越被认为是一种有前途的生物标志物，因为miRNA可以很容易地分离出来，并且在不同的样品处理和分离条件下具有结构稳定性。在这篇综述中，我们提供了目前最先进的miRNA生物发生，功能和讨论的优点，局限性，以及使用循环miRNA作为诊断，预后或预测生物标志物在乳腺癌管理的陷阱。
Effective management of breast cancer depends on early diagnosis and proper monitoring of patients’ response to therapy. However, these goals are difficult to achieve because of the lack of sensitive and specific biomarkers for early detection and for disease monitoring. Accumulating evidence in the past several years has highlighted the potential use of peripheral blood circulating nucleic acids such as DNA, mRNA and micro (mi)RNA in breast cancer diagnosis, prognosis and for monitoring response to anticancer therapy. Among these, circulating miRNA is increasingly recognized as a promising biomarker, given the ease with which miRNAs can be isolated and their structural stability under different conditions of sample processing and isolation. In this review, we provide current state-of-the-art of miRNA biogenesis, function and discuss the advantages, limitations, as well as pitfalls of using circulating miRNAs as diagnostic, prognostic or predictive biomarkers in breast cancer management.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
9.3
作者：
Eichelser, Corinna;Flesch-Janys, Dieter;Schwarzenbach, Heidi
通讯作者：
Schwarzenbach, Heidi
化学疗法前后患者血清的microRNA表达谱。
影响因子：
--
作者：
Diener Y;Walenda T;Jost E;Brümmendorf TH;Bosio A;Wagner W;Bissels U
通讯作者：
Bissels U
影响因子：
14.9
作者：
Altuvia Y;Landgraf P;Lithwick G;Elefant N;Pfeffer S;Aravin A;Brownstein MJ;Tuschl T;Margalit H
通讯作者：
Margalit H
影响因子：
3.7
作者：
Cuk K;Zucknick M;Madhavan D;Schott S;Golatta M;Heil J;Marmé F;Turchinovich A;Sinn P;Sohn C;Junkermann H;Schneeweiss A;Burwinkel B
通讯作者：
Burwinkel B