Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β-Cell Function.
Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β-Cell Function.
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DOI：
10.1002/oby.23174
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
RISE Consortium
中科院分区：
文献类型：
--
作者：
Xiang AH;Martinez MP;Trigo E;Utzschneider KM;Cree-Green M;Arslanian SA;Ehrmann DA;Caprio S;Mohamed PHIH;Hwang DH;Katkhouda N;Nayak KS;Buchanan TA;RISE Consortium
To examine relationship between changes in liver fat and changes in insulin sensitivity and β-cell function 2-years after gastric banding surgery. Data included 23 adults with the surgery who had pre-diabetes or type 2 diabetes (T2D) <1-year and BMI 30–40 kg/m2 at baseline. Body adiposity measures including liver fat content (LFC), insulin sensitivity (M/I) and β-cell responses (acute, steady state and arginine-stimulated maximum [ACPRmax] C-peptide) were assessed at baseline and two-years after surgery. Regression models were used to assess associations adjusted for age and sex. Two-years after surgery, all measures of body adiposity, LFC, fasting and 2-hour glucose and HbA1c significantly decreased; M/I significantly increased; β-cell responses adjusting for M/I did not change significantly. Among adiposity measures, reduction in LFC had the strongest association with M/I increase (r=−0.61, p=0.003). Among β-cell measures, change in LFC was associated with change in ACPRmax adjusted for M/I (r=0.66, p=0.007). Significant reductions in glycemic measures and increase in M/I were observed in individuals with LFC loss > 2.5%. Reduction in LFC after gastric banding surgery appears to be an important factor associated with long-term improvements in insulin sensitivity and glycemic profiles in adults with obesity and prediabetes or early T2D.
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DOI：
10.1126/science.1204265
发表时间：
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期刊：
Science (New York, N.Y.)
影响因子：
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