Malaria in the pregnant woman.
Malaria in the pregnant woman.
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孕妇患有疟疾。
DOI：
10.1007/3-540-29088-5_7
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发表时间：
2005
影响因子：
--
通讯作者：
Fried,M
中科院分区：
文献类型：
--
作者：
Duffy,PE;Fried,M
女性在怀孕期间更容易感染恶性疟原虫，母亲和胎儿患病和死亡的风险都很高。在低传播率地区，所有产次的妇女都有患脑型疟疾等严重综合征的风险，孕产妇和胎儿死亡率也很高。在高传播地区，妇女在第一次怀孕期间最容易受到影响，像脑型疟疾这样的严重综合症并不常见，但严重的孕产妇贫血和低出生体重是常见的后遗症，并造成巨大的生命损失。感染恶性疟原虫的红细胞隔离在胎盘的绒毛间隙中，在那里它们粘附硫酸软骨素A，但不粘附CD36等受体，这些受体通常支持感染非妊娠宿主的寄生虫的粘附。疟疾导致的不良妊娠结局与富含巨噬细胞的浸润和促炎细胞因子（例如肿瘤坏死因子-α）在绒毛间隙中积聚有关。获得针对硫酸软骨素 A (CSA) 结合寄生虫的抗体的女性患胎盘疟疾的可能性较小，并且更有可能生出健康的婴儿。在稳定传播的地区，妇女在连续怀孕期间会获得针对 CSA 结合寄生虫的抗体，这解释了第一次怀孕期间对疟疾的高度易感性，并表明预防妊娠期疟疾的疫苗应针对胎盘寄生虫。疟疾的预防和治疗是流行地区产前保健的重要组成部分，但在怀孕期间需要特别考虑。药物治疗后的复发在怀孕期间更为常见，耐药寄生虫的传播削弱了已知对妇女及其胎儿安全的少数药物的作用。确定新型抗疟药对孕妇的安全性和有效性是当务之急。一种预防妊娠期疟疾的疫苗。恶性疟原虫可能在第一次怀孕前分娩，并对热带地区的母婴健康产生巨大影响。
Women become more susceptible toPlasmodium falciparummalaria during pregnancy, and the risk of disease and death is high for both the mother and her fetus. In low transmission areas, women of all parities are at risk for severe syndromes like cerebral malaria, and maternal and fetal mortality are high. In high transmission areas, where women are most susceptible during their first pregnancies, severe syndromes like cerebral malaria are uncommon, but severe maternal anemia and low birth weight are frequent sequelae and account for an enormous loss of life.P. falciparum-infected red cells sequester in the intervillous space of the placenta, where they adhere to chondroitin sulfate A but not to receptors like CD36 that commonly support adhesion of parasites infecting nonpregnant hosts. Poor pregnancy outcomes due to malaria are related to the macrophage-rich infiltrates and pro-inflammatory cytokines such as tumor necrosis factor-α that accumulate in the intervillous space. Women who acquire antibodies against chrondroitin sulfate A (CSA)-binding parasites are less likely to have placental malaria, and are more likely to deliver healthy babies. In areas of stable transmission, women acquire antibodies against CSA-binding parasites over successive pregnancies, explaining the high susceptibility to malaria during first pregnancy, and suggesting that a vaccine to prevent pregnancy malaria should target placental parasites. Prevention and treatment of malaria are essential components of antenatal care in endemic areas, but require special considerations during pregnancy. Recrudescence after drug treatment is more common during pregnancy, and the spread of drug-resistant parasites has eroded the usefulness of the few drugs known to be safe for the woman and her fetus. Determining the safety and effectiveness of newer antimalarials in pregnant women is an urgent priority. A vaccine that prevents pregnancy malaria due toP. falciparumcould be delivered before first pregnancy, and would have an enormous impact on mother-child health in tropical areas.
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DOI：
10.3109/9780203302255-15
发表时间：
2001
期刊：
The Southeast Asian journal of tropical medicine and public health
影响因子：
--
作者：
F. Nosten;R. McGready
通讯作者：
R. McGready
影响因子：
4.6
作者：
Marzi, M;Vigano, A;Clerici, M
通讯作者：
Clerici, M
印度中部妊娠期疟疾流行病学
影响因子：
11.1
作者：
N. Singh;M. Shukla;V. Sharma
通讯作者：
V. Sharma
影响因子：
4.4
作者：
Ricke, CH;Staalsoe, T;Hviid, L
通讯作者：
Hviid, L
DOI：
10.1016/s0020-7292(02)00225-4
发表时间：
2002-11-01
影响因子：
3.8
作者：
Malhotra, M;Sharma, JB;Arora, R
通讯作者：
Arora, R