MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives.
MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives.
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DOI：
10.3748/wjg.v24.i30.3313
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发表时间：
2018-08-14
影响因子：
4.3
通讯作者：
Kupcinskas J
中科院分区：
文献类型：
--
作者：
Link A;Kupcinskas J
无创性诊断标志物有助于胃癌的早期诊断和提高临床治疗水平。不幸的是，还没有敏感和特异性的筛选生物标志物，目前可用的方法受到疾病性质的限制。GC是一种异质性疾病，在多因素级联致癌过程中发生各种不同的遗传和表观遗传事件。在幽门螺杆菌感染期间，胃粘膜中的microRNA（miRNAs）通常被解除调节，并且以逐步的方式从慢性胃炎，通过癌前状态如萎缩性胃炎和肠上皮化生，到早期异型增生和浸润性癌症。2008年，血液中miRNA的鉴定引起了人们对基于miRNA的GC诊断、预后生物标志物的极大兴趣。本文就miRNA作为胃癌诊断生物标志物的研究进展作一综述。本文对75项与胃癌患者循环miRNA差异表达相关的研究进行了系统评价，并对现有数据的各种异质性方面提出了新的观点，总结了方法学差异。最后，我们强调了几个重要方面，以提高该领域的未来转化和临床研究至关重要。
Non-invasive diagnostic biomarkers may contribute to an early identification of gastric cancer (GC) and improve the clinical management. Unfortunately, no sensitive and specific screening biomarkers are available yet and the currently available approaches are limited by the nature of the disease. GC is a heterogenic disease with various distinct genetic and epigenetic events that occur during the multifactorial cascade of carcinogenesis. MicroRNAs (miRNAs) are commonly deregulated in gastric mucosa during the Helicobacter pylori infection and in stepwise manner from chronic gastritis, through preneoplastic conditions such as atrophic gastritis and intestinal metaplasia, to early dysplasia and invasive cancer. Identification of miRNAs in blood in 2008 led to a great interest on miRNA-based diagnostic, prognostic biomarkers in GC. In this review, we provide the most recent systematic review on the existing studies related to miRNAs as diagnostic biomarkers for GC. Here, we systematically evaluate 75 studies related to differential expression of circulating miRNAs in GC patients and provide novel view on various heterogenic aspects of the existing data and summarize the methodological differences. Finally, we highlight several important aspects crucial to improve the future translational and clinical research in the field.
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影响因子：
24.5
作者：
Han TS;Hur K;Xu G;Choi B;Okugawa Y;Toiyama Y;Oshima H;Oshima M;Lee HJ;Kim VN;Chang AN;Goel A;Yang HK
通讯作者：
Yang HK
血浆 miR-122 和 miR-192 作为早期检测胃癌远处转移的潜在新型生物标志物。
影响因子：
4.2
作者：
Chen, Qingjuan;Ge, Xiaojun;Bi, Feng
通讯作者：
Bi, Feng
DOI：
10.1097/meg.0000000000000952
发表时间：
2017-12-01
影响因子：
2.1
作者：
Goni, Elisabetta;Venerito, Marino;Malfertheiner, Peter
通讯作者：
Malfertheiner, Peter
影响因子：
3.1
作者：
Bornschein, Jan;Leja, Marcis;Malfertheiner, Peter
通讯作者：
Malfertheiner, Peter
血清 MicroRNA 表达谱作为胃癌的诊断依据
影响因子：
2.4
作者：
Huang, Shengkai;Wang, Jia;Huang, Changzhi
通讯作者：
Huang, Changzhi