Telomeres and early-life stress: an overview.
Telomeres and early-life stress: an overview.
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DOI：
10.1016/j.biopsych.2012.06.025
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发表时间：
2013-01-01
影响因子：
10.6
通讯作者：
Tyrka, Audrey R.
中科院分区：
文献类型：
--
作者：
Price, Lawrence H.;Kao, Hung-Teh;Burgers, Darcy E.;Carpenter, Linda L.;Tyrka, Audrey R.
早期不良生活经历的长期后遗症长期以来一直是精神病学的焦点，历史上的神经生物学重点是明显应激反应的生理系统，如下丘脑-垂体-肾上腺（HPA）轴和神经免疫功能。然而，在一般医学文献中越来越多地认识到，这种后遗症可能包括健康状况和生理学上更普遍的改变。端粒生物学的最新发现为探索儿童期虐待对健康的不良影响提供了一条新途径。增殖组织中的端粒长度随着细胞复制而下降，并且这种效应可以被诸如炎症、氧化应激、辐射和毒素等因素加速。端粒长度的减少，作为细胞衰老的代表，与许多慢性躯体疾病有关，这些疾病通常被认为是衰老的疾病，如糖尿病、癌症和心脏病。最近，更短的端粒已被证明在几种精神疾病，特别是抑郁症。成年期各种类型的持续心理社会压力似乎与较短的端粒有关。现在，新的研究表明，与早期生活压力有着强大的，也许是剂量依赖性的关系。这些发现为重新认识经验、身体和精神疾病与衰老之间的复杂关系提供了新的机会。
The long-term sequelae of adverse early-life experiences have long been a focus in psychiatry, with a historic neurobiological emphasis on physiological systems that are demonstrably stress-responsive, such as the hypothalamic-pituitary-adrenal (HPA) axis and neuroimmune function. However, there has been increasing recognition in the general medical literature that such sequelae might encompass more pervasive alterations in health status and physiology. Recent findings in telomere biology have suggested a new avenue for exploring the adverse health effects of childhood maltreatment. Telomere length in proliferative tissues declines with cell replication, and the effect can be accelerated by such factors as inflammation, oxidative stress, radiation, and toxins. Reduced telomere length, as a proxy for cellular aging, has been associated with numerous chronic somatic diseases that are generally considered to be diseases of aging, such as diabetes, cancer, and heart disease. More recently, shorter telomeres have been demonstrated in several psychiatric conditions, particularly depression. Sustained psychosocial stress of a variety of types in adulthood appears to be associated with shorter telomeres. Now, emerging work suggests a robust, and perhaps dose-dependent, relationship with early-life stress. These findings present new opportunities to re-conceptualize the complex relationships between experience, physical and psychiatric disease, and aging.
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影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
影响因子：
5.2
作者：
Epel E;Daubenmier J;Moskowitz JT;Folkman S;Blackburn E
通讯作者：
Blackburn E
DOI：
10.1016/j.mrfmmm.2011.04.003
发表时间：
2012-02-01
影响因子：
2.3
作者：
Aubert, Geraldine;Hills, Mark;Lansdorp, Peter M.
通讯作者：
Lansdorp, Peter M.
影响因子：
3.7
作者：
Daubenmier, Jennifer;Lin, Jue;Blackburn, Elizabeth;Hecht, Frederick M.;Kristeller, Jean;Maninger, Nicole;Kuwata, Margaret;Bacchetti, Peter;Havel, Peter J.;Epel, Elissa
通讯作者：
Epel, Elissa
影响因子：
6.6
作者：
Elvsashagen, Torbjorn;Vera, Elsa;Boye, Birgitte
通讯作者：
Boye, Birgitte