Seminal plasma biomarkers for predicting successful sperm retrieval in patients with nonobstructive azoospermia: a narrative review of human studies.
Seminal plasma biomarkers for predicting successful sperm retrieval in patients with nonobstructive azoospermia: a narrative review of human studies.
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DOI：
10.1186/s12610-023-00184-0
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发表时间：
2023-04-20
影响因子：
2.4
通讯作者：
Yu, Xujun
中科院分区：
文献类型：
--
作者：
Li, Junjun;Yang, Fang;Dong, Liang;Chang, Degui;Yu, Xujun
关键词：
非梗阻性无精子症（NOA）被认为是最严重的男性不育症。在手术睾丸精子提取和辅助生殖技术出现之前，NOA患者很难成为孩子的生父。然而，手术失败可能会对患者造成身体和心理伤害，例如睾丸损伤、疼痛、生育无望和额外费用。因此，预测精子回收（SSR）的成功率对于NOA患者选择是否进行手术至关重要。由于精浆是由睾丸和副性腺分泌的，可以反映精子发生的环境，因此是SSR鉴定的首选。本文的目的是总结现有的证据，并为读者提供一个广泛的概述精浆中的SSR预测的生物标志物。从PUBMED、EMBASE、CENTRAL和Web of Science中共检索了15，390项研究，但删除重复后仅评价了6615项研究。6513篇文章的摘要被排除，因为它们与主题无关。共获得102篇文献的全文，其中21篇纳入本综述。纳入的研究质量从中等到高等不等。在纳入的文献中，手术精子提取方法包括常规睾丸精子提取（TESE）和显微解剖睾丸精子提取（micro-TESE）。目前，精浆中用于预测SSR的生物标志物主要是RNA、代谢物、AMH、B1、B、leptin、survivin、clusterin、LGALS 3BP、ESX 1、TEX 101、TNP 1、DAZ、PRM 1和PRM 2。证据并不完全表明精浆中AMH和INHB对预测SSR有价值。值得注意的是，精浆中的RNA、代谢物和其他生物标志物在预测SSR方面显示出巨大的潜力。然而，现有证据不足以为临床医生提供足够的决策支持，迫切需要更多的前瞻性、大样本量和多中心试验。
Non-obstructive azoospermia (NOA) is considered to be the most severe form of male infertility. Before the emergence of surgical testicular sperm extraction and assisted reproductive technology, NOA patients could hardly become biological fathers of their children. However, failure of the surgery could cause physical and psychological harm to patients such as testicular damage, pain, hopeless of fertility and additional cost. Therefore, predicting the successful sperm retrieval (SSR) is so important for NOA patients to make their choice whether to do the surgery or not. Because seminal plasma is secreted by the testes and accessory gonads, it can reflect the spermatogenic environment, making it a preferential choice for SSR valuation. The purpose of this paper is to summarize the available evidence and provide the reader with a broad overview of biomarkers in seminal plasma for SSR prediction. A total of 15,390 studies were searched from PUBMED, EMBASE, CENTRAL and Web of Science, but only 6615 studies were evaluated after duplications were removed. The abstracts of 6513 articles were excluded because they were irrelevant to the topic. The full texts of 102 articles were obtained, with 21 of them being included in this review. The included studies range in quality from medium to high. In the included articles, surgical sperm extraction methods included conventional testicular sperm extraction (TESE) and microdissection testicular sperm extraction (micro-TESE). Currently, the biomarkers in seminal plasma used to predict SSR are primarily RNAs, metabolites, AMH, inhibin B, leptin, survivin, clusterin, LGALS3BP, ESX1, TEX101, TNP1, DAZ, PRM1 and PRM2. The evidence does not conclusively indicate that AMH and INHB in seminal plasma are valuable to predict the SSR. It is worth noting that RNAs, metabolites and other biomarkers in seminal plasma have shown great potential in predicting SSR. However, existing evidence is insufficient to provide clinicians with adequate decision support, and more prospective, large sample size, and multicenter trials are urgently needed.
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影响因子：
4.1
作者：
Bailey, R;Griswold, MD
通讯作者：
Griswold, MD
影响因子：
6.7
作者：
Duvilla, Emma;Lejeune, Herve;Levy, Rachel
通讯作者：
Levy, Rachel
精浆中睾丸来源的环状 RNA 预测特发性非梗阻性无精子症患者显微切割睾丸精子提取结果的潜力
影响因子：
6.1
作者：
Ji, Chengjian;Wang, Yichun;Song, Ninghong
通讯作者：
Song, Ninghong
影响因子：
2.5
作者：
Gilany, Kambiz;Moazeni-Pourasil, Roudabeh Sadat;Savadi-Shiraz, Elham
通讯作者：
Savadi-Shiraz, Elham
影响因子：
4.5
作者：
Bouhallier, Frantz;Allioli, Nathalie;Rouault, Jean-Pierre
通讯作者：
Rouault, Jean-Pierre