Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques.
Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques.
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DOI：
10.1126/sciadv.adh0974
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发表时间：
2023-10-06
期刊：
影响因子：
13.6
通讯作者：
Anikeeva, Polina
中科院分区：
文献类型：
--
作者：
Garwood, Indie C.;Major, Alex J.;Antonini, Marc-Joseph;Correa, Josefina;Lee, Youngbin;Sahasrabudhe, Atharva;Mahnke, Meredith K.;Miller, Earl K.;Brown, Emery N.;Anikeeva, Polina
记录和调节体内神经活动使得能够研究行为和疾病的神经生理学基础。然而，有一个同时记录和本地化的受体特异性调制翻译工具的缺乏。我们通过翻译以前仅用于啮齿动物研究的多功能纤维神经技术来解决这一限制，使猕猴的皮质和皮质下神经记录和调制成为可能。我们记录单神经元和更广泛的振荡活动，在颅内GABA输注在前运动皮层和壳核。通过应用状态空间模型来表征电生理学的变化，我们发现，即使是适度的局部抑制也会重塑工作记忆任务诱发的神经活动。记录提供了详细的洞察神经递质受体调制的电生理效应在皮层和皮层下结构在清醒的猕猴。我们的研究结果首次证明了多功能纤维在行为非人类灵长类动物神经元活动的因果关系研究中的应用，并为基于纤维的神经技术的临床翻译铺平了道路。多功能纤维使颅内记录和调制，揭示认知过程中的局部抑制作用。
Recording and modulating neural activity in vivo enables investigations of the neurophysiology underlying behavior and disease. However, there is a dearth of translational tools for simultaneous recording and localized receptor-specific modulation. We address this limitation by translating multifunctional fiber neurotechnology previously only available for rodent studies to enable cortical and subcortical neural recording and modulation in macaques. We record single-neuron and broader oscillatory activity during intracranial GABA infusions in the premotor cortex and putamen. By applying state-space models to characterize changes in electrophysiology, we uncover that neural activity evoked by a working memory task is reshaped by even a modest local inhibition. The recordings provide detailed insight into the electrophysiological effect of neurotransmitter receptor modulation in both cortical and subcortical structures in an awake macaque. Our results demonstrate a first-time application of multifunctional fibers for causal studies of neuronal activity in behaving nonhuman primates and pave the way for clinical translation of fiber-based neurotechnology. Multifunctional fibers enable intracranial recording and modulation, revealing effects of local inhibition during cognition.
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影响因子：
17.1
作者：
Dagdeviren C;Ramadi KB;Joe P;Spencer K;Schwerdt HN;Shimazu H;Delcasso S;Amemori KI;Nunez-Lopez C;Graybiel AM;Cima MJ;Langer R
通讯作者：
Langer R
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
DOI：
10.1073/pnas.2014868117
发表时间：
2020-12-08
影响因子：
11.1
作者：
Bastos AM;Lundqvist M;Waite AS;Kopell N;Miller EK
通讯作者：
Miller EK
影响因子：
19
作者：
Antonini, Marc-Joseph;Sahasrabudhe, Atharva;Anikeeva, Polina
通讯作者：
Anikeeva, Polina