Numerical Study on a Focus-Control Method Using Breast Model With Intentionally Assigned High-Absorbing Layer Near Skin for High-Intensity Focused Ultrasound Treatment
Numerical Study on a Focus-Control Method Using Breast Model With Intentionally Assigned High-Absorbing Layer Near Skin for High-Intensity Focused Ultrasound Treatment
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使用乳房模型的焦点控制方法的数值研究，该模型在皮肤附近有意分配高吸收层，用于高强度聚焦超声治疗
DOI：
10.1109/tuffc.2022.3205620
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Takagi Shu
中科院分区：
文献类型：
--
作者：
Zhang Mingzhen;Narumi Ryuta;Azuma Takashi;Okita Kohei;Takagi Shu
为了防止高强度聚焦超声（HIFU）治疗中发生的不良皮肤烧伤，我们数值研究焦点控制方法，如相位补偿（PC）和振幅自适应（AA）。我们有意在皮肤部分附近分配一个高吸收层（HAL），在那里观察到热量产生和组织消融，因为水和乳房皮肤之间的界面有很高的能量损失。结果表明，PC通过提高聚焦峰值和减小聚焦偏移来提高聚焦的有效性，但是PC不抑制皮肤灼伤。AA和PC只有在应用适当的振幅权重时才能消除皮肤灼伤。对用于获得幅度权重的三种算法进行了初步讨论，如下：首先，我们使用距离HAL关闭换能器通道。该算法通过保留100%的输入能量来消除皮肤灼伤，同时引起其他不期望的灼伤。其次，我们使用互相关的幅度权重。它在适当限制大幅度重量后消除皮肤灼伤，同时以较小和较慢的方式产生局灶性坏死。第三，我们将反向传播波（BPW）的均方根（rms）水平引入互相关幅度权重。这种新算法在20秒内产生局灶性消融，而不会造成任何皮肤灼伤。虽然较长的照射时间会导致皮肤灼伤，但由于HIFU治疗需要较短的照射时间以避免超过人类患者的身体承受力，因此结果是令人满意的。此外，这项工作表明，与声峰相关联的焦点控制是不够的。高衰减区域的影响是显著的，应当被捕获。
To prevent undesirable skin burns that occur in high-intensity focused ultrasound (HIFU) treatment, we numerically study focus-control methods, such as phase compensation (PC) and amplitude adaptation (AA). We intentionally assign a high-absorbing layer (HAL) near the part of the skin, where heat generation and tissue ablation are observed, because of high energy loss in the interface between water and breast skin. Results show that PC improves the effectiveness of focusing by enhancing the focal peak and reducing the focal deviation; however, PC does not suppress skin burn. AA and PC eliminate skin burns only if appropriate amplitude weights are applied. A preliminary discussion on three algorithms for obtaining amplitude weights is conducted as follows; First, we switched off transducer channels using distance-to-HAL. This algorithm eliminates skin burns while causing other undesirable burns by preserving 100% input energy. Second, we use cross-correlated amplitude weights. It eliminates skin burn after properly limiting large-amplitude weights while producing focal necrosis in a smaller and slower manner. Third, we introduced root-mean-square (rms) level of back-propagated wave (BPW) into cross-correlated amplitude weights. This new algorithm produces focal ablation in 20 s without causing any skin burn. Although longer irradiation time brings back skin burn, the result is satisfying since short irradiation time is needed in HIFU treatment to avoid exceeding the physical endurance of human patients. Moreover, this work indicates that focus-control associated with an acoustic peak is insufficient. The effects of the high attenuation area are significant and should be captured.
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DOI：
10.1016/j.phpro.2010.01.042
发表时间：
2010
期刊：
影响因子：
--
作者：
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DOI：
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期刊：
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DOI：
10.1007/bf00894973
发表时间：
1979
期刊：
影响因子：
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作者：
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