Granulocyte adherence in pulmonary and systemic arterial blood samples from patients with adult respiratory distress syndrome.
Granulocyte adherence in pulmonary and systemic arterial blood samples from patients with adult respiratory distress syndrome.
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成人呼吸窘迫综合征患者的肺和全身动脉血样中的粒细胞粘附。
DOI：
10.1164/arrd.1984.129.5.798
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Hill,HR
中科院分区：
文献类型：
--
作者：
Zimmerman,GA;Renzetti,AD;Hill,HR
成人呼吸窘迫综合征(ARDS)肺血管损伤的机制之一是肺毛细血管内粒细胞聚集，这是由于循环炎症介质引起的粒细胞黏附增加所致。然而，患有这种综合征的人的粒细胞的黏附特性还没有被描述。在符合ARDS诊断标准的24小时内，我们从14例患者的肺动脉采集全血样本，分析粒细胞与尼龙纤维柱的粘附性。14例患者中有10例粒细胞黏附率低于或等于对照组。12份血浆样本中有8份，包括10份全血粒细胞粘附率降低或正常的患者中的7份，含有增加正常受试者分离的粒细胞粘附率的活性。这些数据表明，在某些ARDS患者中，粒细胞可能对循环黏附促进介质变得不敏感，或者具有不同功能特征的粒细胞在循环中。粒细胞黏附与循环中的血小板数量成正比，表明黏附可能受细胞-细胞相互作用和体液介质的影响。在3名肺摄取铟标记白细胞增加的患者的样本中，粒细胞黏附的平均值是对照样本的75%，这表明在循环细胞黏附没有明显增强的情况下，粒细胞可以在肺内聚集。这些数据还表明，肺内皮细胞的改变，或炎症介质的局部表达，可能是ARDS患者肺微血管中粒细胞聚集的重要决定因素。
The accumulation of granulocytes in lung capillaries, caused by increased granulocyte adherence in response to circulating inflammatory mediators, is proposed as one mechanism of pulmonary vascular injury in the adult respiratory distress syndrome (ARDS). The adherence characteristics of granulocytes from humans with this syndrome have, however, not been described. We assayed the granulocyte adherence to nylon fiber columns using whole blood samples collected from the pulmonary artery of 14 patients within 24 h of satisfying criteria for ARDS. The mean value was 83% of that of normal subjects, and granulocyte adherence was less than or equal to control in samples from 10 of 14 patients. Eight of 12 plasma samples, including 7 of 10 from patients with decreased or normal whole blood granulocyte adherence, contained an activity that increased the adherence of granulocytes isolated from normal subjects. These data suggest that granulocytes may become desensitized to a circulating adherence-promoting mediator or that granulocytes with different functional characteristics circulate in some patients with ARDS. Granulocyte adherence varied directly with the circulating platelet number, indicating that adherence may be influenced by cell-cell interactions as well as by humoral mediators. The granulocyte adherence was a mean of 75% of control samples in samples from 3 patients with increased lung uptake of indium-labeled leukocytes, suggesting that granulocyte accumulation in the lung can occur in the absence of markedly enhanced adherence of circulating cells. These data also suggest that alterations in lung endothelial cells, or the local elaboration of inflammatory mediators, may be important determinants of granulocyte accumulation in the pulmonary microvasculature in established ARDS.
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影响因子：
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作者：
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作者：
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DOI：
10.1172/jci109466
发表时间：
1979
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
J. Fehr;C. Dahinden
通讯作者：
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影响因子：
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作者：
Jorg Fehr;Jorg Fehr;H. S. Jacob
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