The influence of non-nociceptive factors on hot-plate latency in rats.
The influence of non-nociceptive factors on hot-plate latency in rats.
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DOI：
10.1016/j.jpain.2010.06.011
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Morgan MM
中科院分区：
文献类型：
--
作者：
Gunn A;Bobeck EN;Weber C;Morgan MM
热板是一种广泛使用的评估伤害感受的测试。研究了非伤害性因素（体重、性别、活动、习惯和重复测试）对热板潜伏期的影响。体重和热板潜伏期的比较显示出较小但显着的负相关性（轻的大鼠具有更长的潜伏期）。除第 2 - 4 天测试的雌性大鼠外，在测试前使大鼠习惯于测试室 1 小时并不会减少热板潜伏期。随着每日重复测试，热板潜伏期会减少，但这并不是由于运动活动或学习反应的减少引起的。在所有四项试验中，热板上的活动都是一致的，并且之前暴露于室温板会导致与大鼠在热板上反复测试时类似的潜伏期减少。尽管基线热板潜伏期有所减少，但吗啡镇痛效力没有差异。本研究表明，体重、对测试室的习惯和重复测试可以改变基线热板潜伏期，但这些影响很小，对吗啡镇痛作用的影响相对较小。
The hot plate is a widely used test to assess nociception. The effect of non-nociceptive factors (weight, sex, activity, habituation, and repeated testing) on hot plate latency was examined. Comparison of body weight and hot plate latency revealed a small but significant inverse correlation (light rats had longer latencies). Habituating rats to the test room for 1 hr prior to testing did not decrease hot plate latency except for female rats tested on Days 2 - 4. Hot plate latency decreased with repeated daily testing, but this was not caused by a decrease in locomotor activity or learning to respond. Activity on the hot plate was consistent across all four trials, and prior exposure to a room temperature plate caused a similar decrease in latency as rats tested repeatedly on the hot plate. Despite this decrease in baseline hot plate latency, there was no difference in morphine antinociceptive potency. The present study shows that weight, habituation to the test room, and repeated testing can alter baseline hot plate latency, but these effects are small and have relatively little impact on morphine antinociception.
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