Plant NB-LRR signaling: upstreams and downstreams.
Plant NB-LRR signaling: upstreams and downstreams.
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DOI:
10.1016/j.pbi.2011.03.011
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发表时间:
2011-08
影响因子:
9.5
通讯作者:
Coaker G
中科院分区:
文献类型:
--
作者:
Elmore JM;Lin ZJ;Coaker G
Plant disease resistance proteins commonly belong to the nucleotide binding-leucine rich repeat (NB-LRR) protein family. These specialized immune proteins mediate recognition of diverse pathogen-derived effector proteins and initiate potent defense responses. NB-LRRs exhibit a multidomain architecture and each domain appears to have discrete functions depending on the stage of NB-LRR signaling. Novel proteins that were found to interact with the core HSP90 chaperone complex regulate accumulation and activation of NB-LRR immune receptors. Recent studies have also advanced our understanding of how accessory proteins contribute to NB-LRR activation. The dynamic nature of NB-LRR localization to different subcellular compartments before and after activation suggests that NB-LRRs may activate immune responses in multiple parts of the cell. In this review we highlight recent advances in understanding NB-LRR function.
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