Plant NB-LRR signaling: upstreams and downstreams.

Plant NB-LRR signaling: upstreams and downstreams.
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DOI:
10.1016/j.pbi.2011.03.011
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发表时间:
2011-08
影响因子:
9.5
通讯作者:
Coaker G
Coaker G
中科院分区:
生物学2区
文献类型:
--
作者:
Elmore JM;Lin ZJ;Coaker G

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植物性疾病抗性蛋白通常属于核苷酸结合蛋白富含重复蛋白(NB-LRR)蛋白家族。这些专门的免疫蛋白介导了对病原体衍生的效应蛋白的识别,并引发有效的防御反应。 NB-LRRS表现出多域结构,每个域似乎具有离散功能,具体取决于NB-LRR信号的阶段。发现与核心HSP90伴侣复合物相互作用的新型蛋白质调节NB-LRR免疫受体的积累和激活。最近的研究还提高了我们对辅助蛋白如何促进NB-LRR激活的理解。 NB-LRR在激活之前和之后的NB-LRR定位的动态性质表明NB-LRR可以激活细胞多个部分的免疫反应。在这篇综述中,我们重点介绍了了解NB-LRR功能的最新进展。
Plant disease resistance proteins commonly belong to the nucleotide binding-leucine rich repeat (NB-LRR) protein family. These specialized immune proteins mediate recognition of diverse pathogen-derived effector proteins and initiate potent defense responses. NB-LRRs exhibit a multidomain architecture and each domain appears to have discrete functions depending on the stage of NB-LRR signaling. Novel proteins that were found to interact with the core HSP90 chaperone complex regulate accumulation and activation of NB-LRR immune receptors. Recent studies have also advanced our understanding of how accessory proteins contribute to NB-LRR activation. The dynamic nature of NB-LRR localization to different subcellular compartments before and after activation suggests that NB-LRRs may activate immune responses in multiple parts of the cell. In this review we highlight recent advances in understanding NB-LRR function.
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