Monkeypox virus infections in small animal models for evaluation of anti-poxvirus agents.
Monkeypox virus infections in small animal models for evaluation of anti-poxvirus agents.
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DOI：
10.3390/v2122763
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Damon IK
中科院分区：
文献类型：
--
作者：
Hutson CL;Damon IK
研究人类疾病的理想动物模型是利用一种模拟病原体自然传播的感染途径；能够以与导致人类疾病的感染剂量相当的感染剂量获得疾病；以及具有与人类疾病相似的病程、发病率和死亡率。此外，动物模型应该有一种模仿人类病例的传播模式(S)。研究猴痘病毒(MPXV)的小动物模型的发展已经相当广泛，尽管这些模型中只有几个被用于研究抗痘病毒药物，但这种病原体已知的时间相对较短。我们将对迄今为止为研究治疗剂而开发的MPXV小动物模型进行综述。
An ideal animal model for the study of a human disease is one which utilizes a route of infection that mimics the natural transmission of the pathogen; the ability to obtain disease with an infectious dose equivalent to that causing disease in humans; as well having a disease course, morbidity and mortality similar to that seen with human disease. Additionally, the animal model should have a mode(s) of transmission that mimics human cases. The development of small animal models for the study of monkeypox virus (MPXV) has been quite extensive for the relatively short period of time this pathogen has been known, although only a few of these models have been used to study anti-poxvirus agents. We will review those MPXV small animal models that have been developed thus far for the study of therapeutic agents.
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影响因子：
4.4
作者：
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作者：
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Tesh RB
DOI：
10.4269/ajtmh.2007.76.155
发表时间：
2007-01-01
影响因子：
3.3
作者：
Sbrana, Elena;Xiao, Shu-Yuan;Tesh, Robert B.
通讯作者：
Tesh, Robert B.