Experimental infection of prairie dogs with monkeypox virus.
Experimental infection of prairie dogs with monkeypox virus.
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DOI：
10.3201/eid1104.040907
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发表时间：
2005-04
影响因子：
11.8
通讯作者：
Tesh RB
中科院分区：
文献类型：
--
作者：
Xiao SY;Sbrana E;Watts DM;Siirin M;da Rosa AP;Tesh RB
受感染的草原犬可通过呼吸道和皮肤粘膜接触敏感动物和人类传播猴痘病毒。本文报道了猴痘病毒感染草原犬(Cynomys Ludovicianus)的实验研究。经腹腔感染后，所有动物均在11天内死亡。在死亡前几天，从他们的血液和口咽中培养出病毒；在尸检中，大多数被测试的器官都含有猴痘病毒。观察到明显的肝和脾坏死，并伴有轻微的肺部炎症改变。鼻腔(IN)感染后，主要病变在肺部和胸腔。一些感染IN的动物(40%)存活下来，猴痘病毒可以从它们的鼻腔分泌物和口咽中培养22天。幸存动物的嘴唇、舌头和口腔粘膜上也出现了溃烂病变。我们的发现支持了早先的一份报告，即受感染的草原犬可以通过呼吸道和粘膜皮肤接触易感动物和人来传播猴痘病毒。
Infected prairie dogs can transmit monkeypox virus by respiratory and mucocutaneous contact with susceptible animals and humans. Studies of experimental infection of prairie dogs (Cynomys ludovicianus) with monkeypox virus are described. After intraperitoneal infection, all of the animals died within 11 days. Virus was cultured from their blood and oropharynx several days before death; at necropsy, most of the organs tested contained monkeypox virus. Marked hepatic and splenic necrosis were observed, along with mild inflammatory changes in the lungs. After intranasal (IN) infection, the primary pathologic changes were in the lungs and pleural cavity. Some of the IN infected animals (40%) survived, and monkeypox virus could be cultured from their nasal discharge and oropharynx for <22 days. Ulcerative lesions also developed on the lips, tongue, and buccal mucosa of the surviving animals. Our findings support an earlier report, which suggested that infected prairie dogs can transmit monkeypox virus by respiratory and mucocutaneous contact with susceptible animals and persons.
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影响因子：
5.5
作者：
Stienlauf, S;Shoresh, M;Katz, E
通讯作者：
Katz, E
影响因子：
6.4
作者：
Xiao, SY;Zhang, H;Tesh, RB
通讯作者：
Tesh, RB
影响因子：
158.5
作者：
Reed, KD;Melski, JW;Damon, IK
通讯作者：
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影响因子：
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作者：
Tesh, RB;Watts, DM;Xiao, SY
通讯作者：
Xiao, SY
影响因子：
11.8
作者：
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通讯作者：
Veterinary Monkeypox Virus Working Group