Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma.
Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma.
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DOI：
10.1038/ctg.2014.5
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发表时间：
2014-03-13
影响因子：
3.6
通讯作者：
中科院分区：
文献类型：
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胰腺中的脂肪浸润（FI）与高体重指数（BMI）或肥胖以及糖尿病（DM）的患病率呈正相关，而糖尿病（DM）是众所周知的胰腺癌危险因素。然而，胰腺中的 FI 与胰腺癌的关系尚不清楚。最近，我们发现叙利亚金仓鼠的胰腺出现FI，其严重程度随着化学致癌剂诱发的癌变的进展而增加。为了将结果转化为临床环境，我们在一系列接受过胰十二指肠切除术的患者中调查了胰腺中的 FI 是否与胰腺癌相关。在该系列中，我们确定了 102 例胰腺导管腺癌 (PDAC) 病例和 85 例患有除 PDAC 以外癌症的对照病例。根据胰腺切片中脂肪细胞占据的面积，通过组织病理学评估FI的程度，并在病例和对照之间进行比较。病例组胰腺 FI 程度显着高于对照组（中位数 26% vs. 15%，P<0.001），并且与 PDAC 呈正相关，即使在调整 BMI、DM 患病率和其他混杂因素后也是如此（比值比 (OR)，6.1；P<0.001）。 BMI 被认为是与胰腺 FI 最显着相关的因素。胰腺FI与胰腺癌呈正相关。
Fatty infiltration (FI) in the pancreas is positively correlated with high body mass index (BMI) or obesity, and the prevalence of diabetes mellitus (DM), which are well-known risk factors of pancreatic cancer. However, the association of FI in the pancreas with pancreatic cancer is unclear. Recently, we have shown that Syrian golden hamsters feature FI of the pancreas, the severity of which increases along with the progression of carcinogenesis induced by a chemical carcinogen. To translate the results to a clinical setting, we investigated whether FI in the pancreas is associated with pancreatic cancer in a series of patients who had undergone pancreatoduodenectomy. In the series, we identified 102 cases with pancreatic ductal adenocarcinoma (PDAC) and 85 controls with cancers except for PDAC. The degree of FI was evaluated histopathologically from the area occupied by adipocytes in pancreas sections, and was compared between the cases and controls. The degree of FI in the pancreas was significantly higher in cases than in controls (median 26 vs. 15%, P<0.001) and positively associated with PDAC, even after adjustment for BMI, prevalence of DM and other confounding factors (odds ratio (OR), 6.1; P<0.001). BMI was identified as the most significantly associated factor with FI in the pancreas. There is a positive correlation between FI in the pancreas and pancreatic cancer.
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影响因子：
64.8
作者：
Kahn, Steven E.;Hull, Rebecca L.;Utzschneider, Kristina M.
通讯作者：
Utzschneider, Kristina M.
影响因子：
4.8
作者：
Kim, Su-Jin;Nian, Cuilan;McIntosh, Christopher H. S.
通讯作者：
McIntosh, Christopher H. S.
影响因子：
3.3
作者：
Makay, Ozer;Kazimi, Mircelal;Coker, Ahmet
通讯作者：
Coker, Ahmet
影响因子：
6.7
作者：
Schwenzer, Nina F.;Machann, Juergen;Schick, Fritz
通讯作者：
Schick, Fritz
DOI：
10.1002/path.1700920232
发表时间：
1966-01-01
期刊：
JOURNAL OF PATHOLOGY AND BACTERIOLOGY
影响因子：
--
作者：
WALTERS, MNI
通讯作者：
WALTERS, MNI