(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach.
(Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach.
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DOI：
10.1016/j.pt.2016.12.002
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发表时间：
2017-04
影响因子：
9.6
通讯作者：
Grunau C
中科院分区：
文献类型：
--
作者：
Cosseau C;Wolkenhauer O;Padalino G;Geyer KK;Hoffmann KF;Grunau C
基因型×环境的概念，即基因型×环境的相互作用导致表型，被广泛用于描述生物现象。我们建议扩展这个概念的初始概念，用“继承系统”代替G。该系统由基因组和表观基因组组成，共同与环境相互作用以形成表型的发展。在造成肠道血吸虫的人类血吸虫曼氏血吸虫的情况下，与全球健康最相关的表型特征是感染成功。以系统生物学的观点，我们展示了遗传和表观遗传的相互作用如何导致短暂的，但也遗传，表型变异是感染成功的重要因素。关于非基因遗传对进化的重要性有着激烈的争论。曼氏血吸虫表观基因型组分在寄生虫发育和宿主相互作用中起重要作用。我们使用S。mansoni作为一个例子来介绍“遗传系统”的概念，其中基因型和表观基因型成分共同与环境相互作用，以塑造表型的发展。
The G×E concept, in which genotype × environment interactions bring about the phenotype, is widely used to describe biological phenomena. We propose to extend the initial notion of the concept, replacing G by ‘inheritance system’. This system, comprised of both genome and epigenome components, collectively interacts with the environment to shape the development of a phenotype. In the case of the human blood fluke Schistosoma mansoni, responsible for intestinal bilharzia, the phenotypic trait that is most relevant to global health is infection success. Taking a systems biology view we show how genetic and epigenetic interactions result in ephemeral, but also heritable, phenotypic variations that are important for infection success. There is an intense debate about the importance of nongenetic inheritance for evolution. Schistosoma mansoni epigenotype components are important players in parasite development and host interactions. We use S. mansoni as an example to introduce the notion of ‘inheritance system’ in which genotype and the epigenotype components collectively interact with the environment to shape the development of a phenotype.
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影响因子：
2.7
作者：
Agola LE;Steinauer ML;Mburu DN;Mungai BN;Mwangi IN;Magoma GN;Loker ES;Mkoji GM
通讯作者：
Mkoji GM
影响因子：
4
作者：
CIOLI, D;KNOPF, PM;SENFT, AW
通讯作者：
SENFT, AW
影响因子：
3.9
作者：
Fneich, Sara;Theron, Andre;Grunau, Christoph
通讯作者：
Grunau, Christoph
影响因子：
3.4
作者：
Cosseau, C.;Azzi, A.;Grunau, C.
通讯作者：
Grunau, C.
DOI：
10.1590/s0074-02762011000200006
发表时间：
2011-03-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Couto, Flávia FB;Coelho, Paulo Marcos Z;Mattos, Ana Carolina A
通讯作者：
Mattos, Ana Carolina A