Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer
Hydrophilic K2Mn4O8 nanoflowers as a sensitive photothermal theragnosis synergistic platform for the ablation of cancer
复制标题
亲水性 K2Mn4O8 纳米花作为敏感光热治疗协同平台用于消融癌症
DOI：
10.1039/c7nj04242f
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发表时间：
2018-02
影响因子：
3.3
通讯作者：
Hu Junqing
中科院分区：
文献类型：
--
作者：
Peng Yuxuan;Zhang Fei;Huang Xiaojuan;Li Bo;Guan Guoqiang;Zhang Wenlong;Zou Rujia;Lu Xinwu;Hu Junqing
多功能纳米材料实现癌症诊断和治疗的同时，引领了纳米医学的发展趋势。锰基化合物已被开发为优良的磁共振（MR）成像造影剂，但由于其不令人满意的近红外光吸收，它们尚未被证明是光热剂（PTA）。在这里，我们报告了一种亲水性的花状K2 Mn 4 O 8超结构自组装的纳米片，可以同时作为PTA和超灵敏的T1加权磁共振成像（T1-MRI）增强剂。这些K2 Mn 4 O 8纳米花是将808 nm激光能量转化为热能的有效载体，然后在体外和体内有效消融癌细胞。重要的是，由于具有4.6 mM−1 s−1的高纵向弛豫率（r1），它们也可以作为相当令人印象深刻的T1-MRI增强剂。体外和体内实验均证实了其良好的生物相容性、低毒性和高光热转换能力。这是K2 Mn 4 O 8作为PTA的首次应用，并有望促进其他Mn基治疗诊断学。
Achieving cancer diagnosis and treatment simultaneously, multifunctional nanomaterials lead the trend in the development of nanomedicine. Manganese-based compounds have been well developed as excellent magnetic resonance (MR) imaging contrast agents, while they have not been demonstrated as photothermal agents (PTAs) due to their unsatisfactory near-infrared photoabsorption. Herein, we report a hydrophilic flower-like K2Mn4O8 superstructure self-assembled by ultrathin nanosheets that can work simultaneously as a PTA and an ultrasensitive T1-weighted magnetic resonance imaging (T1-MRI) enhancing agent. These K2Mn4O8 nanoflowers are efficient vehicles transforming 808 nm laser energy into thermal energy and then leading to the effective ablation of cancer cells in vitro and in vivo. Importantly, with a high longitudinal relaxivity (r1) of 4.6 mM−1 s−1, they also act as quite impressive T1-MRI enhancing agents. Both in vitro and in vivo experiments confirmed their great biocompatibility, low toxicity and high photothermal conversion capability. This is the first application of K2Mn4O8 as a PTA and would hopefully promote other Mn-based theranostics.
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影响因子：
41.2
作者：
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通讯作者：
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影响因子：
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作者：
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影响因子：
14
作者：
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通讯作者：
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影响因子：
8.6
作者：
Lianzhou Wang;Nobuyuki Sakai;Y. Ebina;and Kazunori Takada;T. Sasaki
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Lianzhou Wang;Nobuyuki Sakai;Y. Ebina;and Kazunori Takada;T. Sasaki
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影响因子：
16.6
作者：
Jin, Yongdong;Jia, Congxian;Huang, Sheng-Wen;O'Donnell, Matthew;Gao, Xiaohu
通讯作者：
Gao, Xiaohu