Examining SARS-CoV-2 Interventions in Residential Colleges Using an Empirical Network.
Examining SARS-CoV-2 Interventions in Residential Colleges Using an Empirical Network.
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DOI：
10.1016/j.ijid.2021.10.008
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Onnela JP
中科院分区：
文献类型：
--
作者：
Hambridge HL;Kahn R;Onnela JP
目标大学已转向SARS-COV-2模型来检查校园重新开放策略。尽管这些研究探索了各种建模技术，但没有人使用经验数据。
在这项研究中，我们使用了使用智能手机蓝牙获得的大学新生的经验接近网络来模拟病毒的传播。我们研究了在实施挑战和不完善的依从性的情况下，调查免疫，测试，孤立，面具戴口罩和社会疏远的作用。
结果我们表明，如果免疫水平较低，则频繁的测试可以大大减少病毒的扩散，但是如果免疫力更加无处不在，其效果受到限制。此外，中等水平的面具戴和社交距离可能会导致累积发生率的额外降低，但是随着免疫力和测试频率的增加，它们的益处迅速降低。但是，如果免疫接种不完美或随着时间的推移而下降，则在这里未研究的情况，频繁的测试和其他干预措施可能会发挥更大的核心作用。
结论我们的发现表明，尽管定期测试和隔离是强大的工具，但如果免疫力高或其他干预措施被广泛采用，则它们的收益有限。如果大学甚至可以达到中等水平的疫苗接种，掩盖和社交距离，则他们可能能够放宽测试频率每四个星期一次。
Objectives Universities have turned to SARS-CoV-2 models to examine campus reopening strategies. While these studies have explored a variety of modeling techniques, none have used empirical data. Methods In this study, we use an empirical proximity network of college freshmen obtained using smartphone Bluetooth to simulate the spread of the virus. We investigate the role of immunization, testing, isolation, mask wearing, and social distancing in the presence of implementation challenges and imperfect compliance. Results We show that frequent testing could drastically reduce the spread of the virus if levels of immunity are low, but its effects are limited if immunity is more ubiquitous. Furthermore, moderate levels of mask wearing and social distancing could lead to additional reductions in cumulative incidence, but their benefit decreases rapidly as immunity and testing frequency increase. However, if immunity from vaccination is imperfect or declines over time, scenarios not studied here, frequent testing and other interventions may play more central roles. Conclusions Our findings suggest that although regular testing and isolation are powerful tools, they have limited benefit if immunity is high or other interventions are widely adopted. If universities can attain even moderate levels of vaccination, masking, and social distancing, they may be able to relax the frequency of testing to once every four weeks.
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DOI：
10.1126/science.abg3055
发表时间：
2021-04-09
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Davies NG;Abbott S;Barnard RC;Jarvis CI;Kucharski AJ;Munday JD;Pearson CAB;Russell TW;Tully DC;Washburne AD;Wenseleers T;Gimma A;Waites W;Wong KLM;van Zandvoort K;Silverman JD;CMMID COVID-19 Working Group;COVID-19 Genomics UK (COG-UK) Consortium;Diaz-Ordaz K;Keogh R;Eggo RM;Funk S;Jit M;Atkins KE;Edmunds WJ
通讯作者：
Edmunds WJ
影响因子：
16.6
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影响因子：
4.6
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2.3
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影响因子：
4.3
作者：
Gressman, Philip T.;Peck, Jennifer R.
通讯作者：
Peck, Jennifer R.