Asymptomatic Natural Human Infections With the Simian Malaria Parasites Plasmodium cynomolgi and Plasmodium knowlesi.
Asymptomatic Natural Human Infections With the Simian Malaria Parasites Plasmodium cynomolgi and Plasmodium knowlesi.
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DOI：
10.1093/infdis/jiy519
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发表时间：
2019-02-15
期刊：
影响因子：
--
通讯作者：
White NJ
中科院分区：
文献类型：
--
作者：
Imwong M;Madmanee W;Suwannasin K;Kunasol C;Peto TJ;Tripura R;von Seidlein L;Nguon C;Davoeung C;Day NPJ;Dondorp AM;White NJ
在东南亚，诺氏疟原虫是长尾猕猴（Macaca fasciculis）的寄生虫，是人类疟疾的重要原因。食蟹猴疟原虫也常见感染这些猴子，但之前只报道过一例自然获得性症状的人类病例。在柬埔寨西部拜林和马德望的 23 个村庄进行了涉及 5422 名受试者（年龄 6 个月至 65 岁）的疟计量研究。使用高容量定量 PCR (uPCR) 对血液样本进行寄生虫检测和基因分型。 14732 份样本中的 1361 份检测出无症状疟疾寄生虫感染（9.2%）。在居住在森林地区附近的 21 个人中发现了非人类灵长类疟疾寄生虫的无症状感染；食蟹猴检出 11 例，诺氏疟原虫检出 8 例，间日疟原虫和食蟹猴检出 2 例。只有 2 名受试者为女性，14 名受试者为男性，年龄 20-40 岁。食蟹猴感染中的几何平均寄生虫密度为 3604 个寄生虫/mL，诺氏疟原虫感染中的几何平均寄生虫密度为 52488 个寄生虫/mL。所有食蟹猴分离株都具有野生型二氢叶酸还原酶基因，这与人类疟疾寄生虫中突变的发生率非常高相反。两名受试者在首次感染后 3 个月后再次出现食蟹猴无症状症状。无症状的自然获得性食蟹猴和诺氏疟原虫感染都可能发生在人类身上。 NCT01872702。柬埔寨西部的流行病学研究确定了 21 名无症状猴疟疾寄生虫感染受试者（8 名诺氏疟原虫感染，13 名食蟹猴疟原虫感染）。这些寄生虫占所有已发现的疟疾寄生虫的 1.9%。
In Southeast Asia, Plasmodium knowlesi, a parasite of long-tailed macaques (Macaca fascicularis), is an important cause of human malaria. Plasmodium cynomolgi also commonly infects these monkeys, but only one naturally acquired symptomatic human case has been reported previously. Malariometric studies involving 5422 subjects (aged 6 months to 65 years) were conducted in 23 villages in Pailin and Battambang, western Cambodia. Parasite detection and genotyping was conducted on blood samples, using high-volume quantitative PCR (uPCR). Asymptomatic malaria parasite infections were detected in 1361 of 14732 samples (9.2%). Asymptomatic infections with nonhuman primate malaria parasites were found in 21 individuals living close to forested areas; P. cynomolgi was found in 11, P. knowlesi was found in 8, and P. vivax and P. cynomolgi were both found in 2. Only 2 subjects were female, and 14 were men aged 20–40 years. Geometric mean parasite densities were 3604 parasites/mL in P. cynomolgi infections and 52488 parasites/mL in P. knowlesi infections. All P. cynomolgi isolates had wild-type dihydrofolate reductase genes, in contrast to the very high prevalence of mutations in the human malaria parasites. Asymptomatic reappearance of P. cynomolgi occurred in 2 subjects 3 months after the first infection. Asymptomatic naturally acquired P. cynomolgi and P. knowlesi infections can both occur in humans. NCT01872702. Epidemiological studies in western Cambodia identified 21 subjects with asymptomatic monkey malaria parasite infections (8 with P. knowlesi infection and 13 with P. cynomolgi infection). These parasites represented 1.9% of all identified malaria parasites.
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影响因子：
20.3
作者：
Kosaisavee, Varakorn;Suwanarusk, Rossarin;Russell, Bruce
通讯作者：
Russell, Bruce
影响因子：
6.4
作者：
Imwong, Mallika;Snounou, Georges;White, Nicholas J.
通讯作者：
White, Nicholas J.
影响因子：
6.4
作者：
Fornace, Kimberly M.;Nuin, Nor Afizah;Drakeley, Chris J.
通讯作者：
Drakeley, Chris J.
影响因子：
3
作者：
Herdiana H;Cotter C;Coutrier FN;Zarlinda I;Zelman BW;Tirta YK;Greenhouse B;Gosling RD;Baker P;Whittaker M;Hsiang MS
通讯作者：
Hsiang MS
影响因子：
9.4
作者：
Perandin, F;Manca, N;Chezzi, C
通讯作者：
Chezzi, C