Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases.
Optical Coherence Tomography in Alzheimer's Disease and Other Neurodegenerative Diseases.
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DOI：
10.3389/fneur.2017.00701
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发表时间：
2017
影响因子：
3.4
通讯作者：
Koronyo-Hamaoui M
中科院分区：
文献类型：
--
作者：
Doustar J;Torbati T;Black KL;Koronyo Y;Koronyo-Hamaoui M
在过去的十年里，大量的证据证明了患有轻度认知障碍、阿尔茨海默病（AD）、帕金森病（PD）和其他神经退行性疾病的患者视网膜的各种病理过程。大量研究表明，视网膜是大脑发育过程中形成的中枢神经系统组织，它深受阿尔茨海默病的影响。阿尔茨海默病患者的视网膜具有最早可检测到的疾病特异性体征，即淀粉样β蛋白（Aβ）斑块，其视网膜经历了大量神经节细胞变性、视网膜神经纤维层变薄、视神经轴突投射丧失等异常。最近的研究描述了视网膜中位于神经元变性部位的Aβ斑块，并在上、下象限的中、远外围成团发生，这些区域以前被忽视。在帕金森病、亨廷顿氏病和多发性硬化症患者的视网膜中也发现了多种结构和/或疾病特异性改变。视网膜和大脑之间的病理关系促使了成像工具的发展，这些工具旨在无创地检测和监测活着的患者的这些迹象。其中一种工具是光学相干断层扫描（OCT），它独特地提供高分辨率的二维横截面成像和三维体积测量。因此，OCT成为评估体内视网膜异常的重要方法，并且确实提供了多种参数，可以区分正常老年人和神经退行性疾病患者。除了使用视网膜光学眼底成像（最近允许通过外周视网膜的宽视场视图来检测和量化活的AD患者的淀粉样斑块）之外，OCT的一个主要优势是能够测量特定视网膜层的体积变化。OCT已被证明在分析与疾病发病机制一致的视网膜结构异常方面特别有用。在这篇综述中，我们总结了AD和其他神经退行性疾病患者视网膜OCT的发现。未来的研究应该探索将成像早期标志体征与可及视网膜中的结构功能生物标志物结合起来，作为评估这些患者的风险、疾病进展和治疗效果的实用手段。
Over the past decade, a surge of evidence has documented various pathological processes in the retina of patients suffering from mild cognitive impairment, Alzheimer’s disease (AD), Parkinson’s disease (PD), and other neurodegenerative diseases. Numerous studies have shown that the retina, a central nervous system tissue formed as a developmental outgrowth of the brain, is profoundly affected by AD. Harboring the earliest detectable disease-specific signs, amyloid β-protein (Aβ) plaques, the retina of AD patients undergoes substantial ganglion cell degeneration, thinning of the retinal nerve fiber layer, and loss of axonal projections in the optic nerve, among other abnormalities. More recent investigations described Aβ plaques in the retina located within sites of neuronal degeneration and occurring in clusters in the mid- and far-periphery of the superior and inferior quadrants, regions that had been previously overlooked. Diverse structural and/or disease-specific changes were also identified in the retina of PD, Huntington’s disease, and multiple sclerosis patients. The pathological relationship between the retina and brain prompted the development of imaging tools designed to noninvasively detect and monitor these signs in living patients. One such tool is optical coherence tomography (OCT), uniquely providing high-resolution two-dimensional cross-sectional imaging and three-dimensional volumetric measurements. As such, OCT emerged as a prominent approach for assessing retinal abnormalities in vivo, and indeed provided multiple parameters that allowed for the distinction between normal aged individuals and patients with neurodegenerative diseases. Beyond the use of retinal optical fundus imaging, which recently allowed for the detection and quantification of amyloid plaques in living AD patients via a wide-field view of the peripheral retina, a major advantage of OCT has been the ability to measure the volumetric changes in specified retinal layers. OCT has proven to be particularly useful in analyzing retinal structural abnormalities consistent with disease pathogenesis. In this review, we provide a summary of OCT findings in the retina of patients with AD and other neurodegenerative diseases. Future studies should explore the combination of imaging early hallmark signs together with structural–functional biomarkers in the accessible retina as a practical means of assessing risk, disease progression, and therapeutic efficacy in these patients.
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DOI：
10.1093/brain/awq133
发表时间：
2010-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Calabresi PA;Balcer LJ;Frohman EM
通讯作者：
Frohman EM
影响因子：
3.7
作者：
Boppart, SA
通讯作者：
Boppart, SA
影响因子：
2.9
作者：
BLANKS, JC;HINTON, DR;MILLER, CA
通讯作者：
MILLER, CA
影响因子：
8.6
作者：
Andrade, Carlos;Beato, Joao;Garrett, Carolina
通讯作者：
Garrett, Carolina
影响因子：
4.2
作者：
Bagci, Ahmet Murat;Shahidi, Mahnaz;Ansari, Rashid;Blair, Michael;Blair, Norman Paul;Zelkha, Ruth
通讯作者：
Zelkha, Ruth